C. Caroline O’Hare

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index615citations32works0.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(9), Cancer therapeutics and mechanisms(9), RNA and protein synthesis mechanisms(4), Bioactive Compounds and Antitumor Agents(4), Synthesis and Biological Evaluation(4)

Publications31 total

Treatment of Chronic Refractory Cough in Adults: Focus on Neuromodulators and Other Therapeutic Modalities
Journal of Pharmacy Technology·2020· 3 cited
Workflow Improvement and the Use of PDSA Cycles: An Exploration Using Screening, Brief Intervention, and Referral to Treatment (SBIRT) Integration
Quality Management in Health Care·2020· 11 cited
Developing Quality Metrics Regarding the Concomitant Use of Opioids and Benzodiazepines and Benzodiazepine-Like Hypnotics
Research in Social and Administrative Pharmacy·2019
DNA sequence recognition in crosslinked polyamides: The head group and linker lengti affinity and specificity
2016
Pharmacogenetics—Statistical Considerations
Advances in predictive, preventive and personalised medicine·2015
Sequence specific and high affinity recognition of 5′-ACGCGT-3′ by rationally designed pyrrole-imidazole H-pin polyamides: Thermodynamic and structural studies
Bioorganic & Medicinal Chemistry·2008· 16 citedOpen Access
Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78
Molecular Cancer Therapeutics·2008· 59 citedOpen Access
Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm
Bioorganic & Medicinal Chemistry·2008· 16 cited
Targeting the inverted CCAAT Box-2 of the topoisomerase IIα gene: DNA sequence selective recognition by a polyamide–intercalator as a staggered dimer
Bioorganic & Medicinal Chemistry·2007· 18 cited
Sequence Recognition in the Minor Groove of DNA by Covalently Linked Formamido Imidazole−Pyrrole−Imidazole Polyamides:  Effect of H-Pin Linkage and Linker Length on Selectivity and Affinity
Biochemistry·2007· 18 cited
MEDI 309-Regulation of the topoisomerase II alpha gene using polyamides that binds to the inverted CCAAT box present in the promoter
UCL Discovery (University College London)·2007
Modulation of topoisomerase IIα expression by a DNA sequence-specific polyamide
Molecular Cancer Therapeutics·2007· 24 citedOpen Access
Physical and Structural Basis for the Strong Interactions of the -ImPy- Central Pairing Motif in the Polyamide f-ImPyIm
Biochemistry·2006· 72 cited
Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIα promoter and modulation of gene expression in cells
Bioorganic & Medicinal Chemistry Letters·2006· 17 cited
Synthesis and Evaluation of an Intercalator–Polyamide Hairpin Designed to Target the Inverted CCAAT Box 2 in the Topoisomerase IIα Promoter
ChemBioChem·2006· 11 cited
DNA interstrand crosslinking agents: Synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD)
Bioorganic & Medicinal Chemistry Letters·2006· 16 cited
Molecular recognition of polyamides with DNA: A study on the strong binding of f-ImPyIm to its cognate DNA, ACGCGT
UCL Discovery (University College London)·2006
CCDC 608670: Experimental Crystal Structure Determination
The Cambridge Structural Database·2006Open Access
Inhibition of DNA binding of the transcription factor complex NF-Y by a pyrrolobenzodiazepine-polyamide conjugate.
UCL Discovery (University College London)·2005
Design of a Hairpin Polyamide, ZT65B, for Targeting the Inverted CCAAT Box (ICB) Site in the Multidrug Resistant (<i>MDR1</i>) Gene
ChemBioChem·2005· 12 cited
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Frequent Co-authors

John A. Hartley(21), Moses Lee(10), Daniel Hochhauser(8), Hilary Mackay(7), Binh Nguyen(7), Minal Kotecha(6), Jérôme Kluza(6), W. David Wilson(6), Toni Brown(5), Karen L. Buchmueller(4), Stephen M. Lacy(4), Zarmeen Taherbhai(3), Chrystal D. Bruce(3), Laurie L. Parker(3), Roberto Mantovani(3), John Butler(3), J.A. Hartley(3), Peter B. Uthe(3), Alan Sielaff(3), Joachim Baumgart(2)