João F. Passos

Mayo Clinic — United States

Medicine · Health Sciences

68h-index29.1kcitations193works24.82yr avg
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Research Topics

Telomeres, Telomerase, and Senescence(118), Genetics, Aging, and Longevity in Model Organisms(52), Neutrophil, Myeloperoxidase and Oxidative Mechanisms(30), Mitochondrial Function and Pathology(23), Single-cell and spatial transcriptomics(15)

Publications190 total

Mitochondrial RNA cytosolic leakage drives the SASP
Nature Communications·2025· 3 citedOpen Access
4i (iterative indirect immunofluorescence imaging) PROTOCOL For FFPE slides - Benchmarking project Sennet v1
2025Open Access
Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues
The EMBO Journal·2025· 4 citedOpen Access
Comprehensive healthspan assessments and influence of sex as a biological variable in aging rats
2025Open Access
Advancing biological understanding of cellular senescence with computational multiomics
Nature Genetics·2025· 10 citedOpen Access
Optimized Synthetic Flavonols Support Senescence Clearance and Lung Fibrosis Resolution
ACS Pharmacology & Translational Science·2025Open Access
Cytosolic DNA crosstalk in senescence: a new axis of inflammatory signaling?
The EMBO Journal·2025· 5 citedOpen Access
Inactivation of Histone Chaperone <scp>HIRA</scp> Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells
Aging Cell·2025Open Access
Mitochondrial Reactive Oxygen Species and Endoplasmic Reticulum Stress in Hyperoxia-induced Senescence in Developing Human Airway Smooth Muscle
American Journal of Respiratory and Critical Care Medicine·2025
Hyperoxia-induced senescence in fetal airway smooth muscle cells: role of mitochondrial reactive oxygen species and endoplasmic reticulum stress
American Journal of Physiology-Lung Cellular and Molecular Physiology·2025Open Access
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells
Nature Communications·2025· 22 citedOpen Access
Advances In Interventional Cardiology. Emerging Technologies In Angioplasty And Drug-Eluting Stents
International Journal of Research Publication and Reviews·2025Open Access
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Nature Reviews Cardiology·2025· 35 citedOpen Access
Extracellular Matrix-Associated Molecules of Senescent Cells Induce a Senescence Phenotype in Proliferative Cells Via Tgf-Β Signaling Pathway
SSRN Electronic Journal·2025Open Access
Mitochondrial metabolism and epigenetic crosstalk drive the SASP
2024· 3 citedOpen Access
CELL SENESCENCE AND MITOCHONDRIA: A MATTER OF LIFE OR DEATH
Innovation in Aging·2024Open Access
NEW INSIGHTS INTO MITOCHONDRIA AND CELLULAR SENESCENCE
Innovation in Aging·2024Open Access
ADVANCES IN CELLULAR SENESCENCE
Innovation in Aging·2024Open Access
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
Aging·2024· 34 citedOpen Access
Senescent cell transplantation into the skin induces age‐related peripheral dysfunction and cognitive decline
Aging Cell·2024· 18 citedOpen Access
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Frequent Co-authors

Diana Jurk(24), Thomas von Zglinicki(16), James L. Kirkland(12), Tamar Tchkonia(11), Peter D. Adams(10), Stella Victorelli(10), Sundeep Khosla(9), Jodie Birch(8), Nathan K. LeBrasseur(8), Anthony B. Lagnado(8), Mikołaj Ogrodnik(8), Gabriele Saretzki(8), Clara Correia‐Melo(8), Graeme Hewitt(7), Marissa J. Schafer(6), Hanna Salmonowicz(6), Derek A. Mann(6), Viktor I. Korolchuk(6), Laura J. Niedernhofer(5), Paul D. Robbins(5)