James L. Kirkland

Cedars-Sinai Medical Center — United States

Medicine · Health Sciences

111h-index58.2kcitations494works12.52yr avg
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Research Topics

Telomeres, Telomerase, and Senescence(170), Adipokines, Inflammation, and Metabolic Diseases(79), Adipose Tissue and Metabolism(79), Genetics, Aging, and Longevity in Model Organisms(76), Glioma Diagnosis and Treatment(40)

Publications491 total

Senolytic Changes in Murine Arteriovenous Fistulas with CKD
Kidney360·2026Open Access
The Yin and Yang of cellular senescence in ischemia-induced myocardial injury
Trends in Cardiovascular Medicine·2025Open Access
Early and Late Myocardial Effects of Proton Beam Cardiac Radioablation
JACC. Clinical electrophysiology·2025· 1 cited
Space radiation induces distinct senescent phenotypes: Implications for space travel
npj Aging·2025Open Access
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
Cell Metabolism·2025· 3 cited
Senotherapeutics for metabolic disease and diabetic complications
Journal of Internal Medicine·2025Open Access
Pharmacological clearance of senescent cells reduces inflammation, endothelial damage and cardiac fibrosis in HFpEF
Cardiovascular Research·2025· 1 citedOpen Access
Translating cellular senescence research into clinical practice for metabolic disease
Nature Reviews Endocrinology·2025· 1 cited
Effects of inhibition of Janus kinase signalling during controlled mechanical ventilation on the rate of skeletal muscle protein synthesis
The Journal of Physiology·2025· 1 citedOpen Access
Comprehensive healthspan assessments and influence of sex as a biological variable in aging rats
2025Open Access
Advancing biological understanding of cellular senescence with computational multiomics
Nature Genetics·2025· 10 citedOpen Access
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
2025Open Access
<scp>KDM4</scp> Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence‐Associated Secretory Phenotype
Aging Cell·2025· 2 citedOpen Access
Paracrine Bone-Derived Senescent Secretome Induces Spatially Patterned ECM and Biomechanical Vulnerability in Human Brain Organoids
2025Open Access
Foundations and Strategic Vision of the Canadian Translational Geroscience Network
The Journals of Gerontology Series A·2025Open Access
Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease
Cell Death and Disease·2025· 9 citedOpen Access
A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling
2025Open Access
Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer’s disease
Neurotherapeutics·2025· 8 citedOpen Access
Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice
Advanced Science·2025· 17 citedOpen Access
Abstract 603: Repurposing the plant-derived compound apigenin in anticancer and antiaging pipelines
Cancer Research·2025
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Frequent Co-authors

Tamar Tchkonia(41), Tamar Pirtskhalava(18), Nathan K. LeBrasseur(17), Yi Zhu(15), Nino Giorgadze(12), Paul D. Robbins(11), Laura J. Niedernhofer(11), Mikołaj Ogrodnik(11), Allyson K. Palmer(10), Sundeep Khosla(10), Ming Xu(10), Diana Jurk(10), Kurt O. Johnson(9), Larissa Prata(8), João F. Passos(8), Michael D. Jensen(8), Jordan D. Miller(6), Joshua N. Farr(6), Heike Fuhrmann‐Stroissnigg(6), Megan Weivoda(6)