Tamar Pirtskhalava

Cedars-Sinai Medical Center — United States

Medicine · Health Sciences

35h-index17.9kcitations60works9.02yr avg
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Research Topics

Telomeres, Telomerase, and Senescence(27), Adipokines, Inflammation, and Metabolic Diseases(19), Adipose Tissue and Metabolism(14), Neutrophil, Myeloperoxidase and Oxidative Mechanisms(11), Fatty Acid Research and Health(4)

Publications59 total

Senolytic‐Resistant Senescent Cells Have a Distinct <scp>SASP</scp> Profile and Functional Impact: The Path to Developing Senosensitizers
Aging Cell·2025· 1 citedOpen Access
Space radiation induces distinct senescent phenotypes: Implications for space travel
npj Aging·2025Open Access
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
Cell Metabolism·2025· 3 cited
The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits
2025Open Access
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
2025Open Access
A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease
EBioMedicine·2025· 38 citedOpen Access
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function
Cell Metabolism·2024· 33 citedOpen Access
Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden
2024· 6 citedOpen Access
Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
Communications Biology·2024Open Access
Transplanting old organs promotes senescence in young recipients
American Journal of Transplantation·2023· 27 citedOpen Access
Senescence markers in subcutaneous preadipocytes differ in childhood‐ versus adult‐onset obesity before and after weight loss
Obesity·2023· 11 citedOpen Access
A chronic wound model to investigate skin cellular senescence
Aging·2023· 15 citedOpen Access
ORALLY ACTIVE, CLINICALLY TRANSLATABLE SENOLYTICS RESTORE Α-KLOTHO IN MICE AND HUMANS
Innovation in Aging·2022Open Access
LB1026 Role of skin cellular senescence in chronic wound healing
Journal of Investigative Dermatology·2022
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
EBioMedicine·2022· 86 citedOpen Access
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
Aging·2021· 84 citedOpen Access
Senolytics reduce coronavirus-related mortality in old mice
Science·2021· 308 citedOpen Access
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
Aging Cell·2021· 375 citedOpen Access
Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice
Communications Biology·2021· 64 citedOpen Access
Effect of Combined Dasatinib and Fisetin Treatment on Senescent Cell Clearance in Monkeys
Innovation in Aging·2020· 2 citedOpen Access
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Frequent Co-authors

Tamar Tchkonia(48), James L. Kirkland(48), Nino Giorgadze(24), Yi Zhu(18), Nathan K. LeBrasseur(17), Kurt O. Johnson(15), Ming Xu(14), Allyson K. Palmer(13), Larissa Prata(12), Mikołaj Ogrodnik(11), Michael B. Stout(10), Diana Jurk(10), Michael D. Jensen(10), Sundeep Khosla(9), Paul D. Robbins(9), Thomas A. White(9), Laura J. Niedernhofer(8), Christina L. Inman(8), Megan Weivoda(7), Marissa J. Schafer(7)