Hideyoshi Harashima

Hokkaido University of Science — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

87h-index30.7kcitations674works8.02yr avg
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Research Topics

RNA Interference and Gene Delivery(381), Advanced biosensing and bioanalysis techniques(210), Virus-based gene therapy research(118), Nanoparticle-Based Drug Delivery(97), Immunotherapy and Immune Responses(60)

Publications674 total

The effect of guide RNA thermal denaturation on the quality of Cas9 ribonucleoprotein-loaded lipid nanoparticle formulations
RSC Pharmaceutics·2025Open Access
Examining the Impact of Storage Conditions on the Stability of a Liquid Formulation of mRNA-Loaded Lipid Nanoparticles
Pharmaceutics·2025· 1 citedOpen Access
Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in MtDNA (mt-Atp8)
Scientific Reports·2025· 10 citedOpen Access
Microfluidic Production of Exosome-Mimicking Lipid Nanoparticles for Enhanced RNA Delivery: Role of Exosomal Proteins
ACS Applied Materials & Interfaces·2025· 6 citedOpen Access
Selective vascular disrupting therapy by lipid nanoparticle-mediated Fas ligand silencing and stimulation of STING
Biomaterials·2025· 2 cited
Harnessing the composition of lipid nanoparticles to selectively deliver mRNA to splenic immune cells for anticancer vaccination
Drug Delivery and Translational Research·2025· 6 cited
Marginal-zone B cells as promising targets of an mRNA-loaded, lipid-nanoparticle cancer vaccine
Next Nanotechnology·2025· 3 citedOpen Access
A new strategy for the extrahepatic delivery of lipid-based nanomedicines: a protein corona-mediated selective targeting system based on an ionizable cationic lipid library
RSC Pharmaceutics·2025· 4 citedOpen Access
Targeting Tumor Endothelial Cells by <scp>EGCG</scp> Using Specific Liposome Delivery System Inhibits Vascular Inflammation and Thrombosis
Cancer Medicine·2024· 4 citedOpen Access
Different Effects of Berberine Delivery to Mitochondria on Cells Derived from the Neural Crest
Biological and Pharmaceutical Bulletin·2024· 2 citedOpen Access
Impact of Lipid Tail Length on the Organ Selectivity of mRNA-Lipid Nanoparticles
Nano Letters·2024· 18 citedOpen Access
Engineering branched ionizable lipid for hepatic delivery of clustered regularly interspaced short palindromic repeat-Cas9 ribonucleoproteins
iScience·2024· 6 citedOpen Access
Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids
Communications Biology·2024· 53 citedOpen Access
The impact of, and expectations for, lipid nanoparticle technology: From cellular targeting to organelle targeting
Journal of Controlled Release·2024· 17 cited
Understanding Gene Involvement in Hepatocellular Carcinoma: Implications for Gene Therapy and Personalized Medicine
Pharmacogenomics and Personalized Medicine·2024· 4 citedOpen Access
Investigation of the Nanoparticulation Method and Cell-Killing Effect following the Mitochondrial Delivery of Hydrophobic Porphyrin-Based Photosensitizers
International Journal of Molecular Sciences·2024· 2 citedOpen Access
Vaccination with a combination of STING agonist-loaded lipid nanoparticles and CpG-ODNs protects against lung metastasis via the induction of CD11bhighCD27low memory-like NK cells
Experimental Hematology and Oncology·2024· 16 citedOpen Access
Activation of Mitochondrial Oxygen Consumption Rate by Delivering Coenzyme Q10 to Mitochondria of Rat Skeletal Muscle Cell (L6)
Journal of Pharmaceutical Sciences·2024· 6 citedOpen Access
Human cardiosphere-derived cells with activated mitochondria for better myocardial regenerative therapy
Journal of Controlled Release·2024· 10 citedOpen Access
Paradigm-shift and Nobel Prize
Drug Delivery System·2024Open Access
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Frequent Co-authors

Hidetaka Akita(23), Kentaro Kogure(12), Hiroto Hatakeyama(12), Shiroh Futaki(12), Yusuke Sato(12), Ikramy A. Khalil(7), Mamoru Hyodo(6), Hiroshi Kiwada(5), Yuma Yamada(5), Masatoshi Maeki(5), Manabu Tokeshi(5), Yu Sakurai(4), Hiroyuki Kamiya(4), Takashi Nakamura(4), Yoshinobu Baba(4), Ayman El‐Sayed(3), Motoi Oishi(3), Yukio Nagasaki(3), Hiroshi Kikuchi(3), Tatsuhiro Ishida(3)