Hidetaka Akita

Tohoku University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

58h-index13.6kcitations362works5.42yr avg
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Research Topics

RNA Interference and Gene Delivery(164), Advanced biosensing and bioanalysis techniques(99), Virus-based gene therapy research(63), Immunotherapy and Immune Responses(30), Nanoparticle-Based Drug Delivery(27)

Publications362 total

Combining Anti-Inflammatory Drugs and Cell-Specific Expression-Suppression Reduces the Adjuvant Activity of mRNA-LNPs
Molecular Pharmaceutics·2026Open Access
Lipid Nanoparticle-mediated mRNA delivery system into preimplantation embryos
Biology of Reproduction·2025
Lipid nanoparticle-encapsulated microRNA-192: An anti-inflammatory adjuvant that enhances vaccine efficacy in aged mice
Molecular Therapy — Nucleic Acids·2025· 1 citedOpen Access
Combination of ionizable lipids with oleic acid and vitamin E scaffolds for RNA cancer vaccine delivery
Journal of Controlled Release·2025Open Access
Neoantigen mRNA vaccines induce progenitor-exhausted T cells that support anti-PD-1 therapy in gastric cancer with peritoneal metastasis
Gastric Cancer·2025· 2 citedOpen Access
Modulating Immunogenicity and Reactogenicity in mRNA-Lipid Nanoparticle Vaccines through Lipid Component Optimization
ACS Nano·2025· 15 citedOpen Access
Investigation of a novel method of gene transduction in early embryo
Journal of Reproductive Immunology·2025Open Access
Systemic mRNA Delivery into the Muscle of Duchenne Muscular Dystrophy Model Mice Using Alpha-Dystroglycan Binding Peptide Modified Lipid Nanoparticles
Biological and Pharmaceutical Bulletin·2025Open Access
Antibody-dependent cellular cytotoxicity of anti-programmed death-ligand 1 antibodies for T cells attenuate their antitumor efficacy in a murine tumor model
International Journal of Pharmaceutics·2025Open Access
A Post-Encapsulation Method for the Preparation of mRNA-LNPs via the Nucleic Acid-Bridged Fusion of mRNA-Free LNPs
Nano Letters·2025· 10 citedOpen Access
Antibody-Dependent Cellular Cytotoxicity of Anti-Pd-L1 Antibodies for T Cells Attenuate Their Antitumor Efficacy in a Murine Tumor Model
SSRN Electronic Journal·2025Open Access
Intracellular Environment–responsive Lipids for RNA Drug Discovery: Design and Function
MEMBRANE·2025
Control of the Particle Trafficking and Dynamics of the Lymphatic System and of the Cellular Microenvironment
2025Open Access
Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 influenza virus with reduced adverse reactions
Molecular Therapy·2024· 25 citedOpen Access
Effect of Anti-PEG Antibody on Immune Response of mRNA-Loaded Lipid Nanoparticles
Molecular Pharmaceutics·2024· 13 citedOpen Access
Author Correction: EVs-miR-17-5p attenuates the osteogenic differentiation of vascular smooth muscle cells potentially via inhibition of TGF-β signaling under high glucose conditions
Scientific Reports·2024Open Access
NMR-based analysis of impact of siRNA mixing conditions on internal structure of siRNA-loaded LNP
Journal of Controlled Release·2024· 9 citedOpen Access
EVs-miR-17-5p attenuates the osteogenic differentiation of vascular smooth muscle cells potentially via inhibition of TGF-β signaling under high glucose conditions
Scientific Reports·2024· 11 citedOpen Access
The stress-responsive cytotoxic effect of diesel exhaust particles on lymphatic endothelial cells
Scientific Reports·2024· 8 citedOpen Access
Lymphatic Endothelial Cells Produce Chemokines in Response to the Lipid Nanoparticles Used in RNA Vaccines
Biological and Pharmaceutical Bulletin·2024· 5 citedOpen Access
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Frequent Co-authors

Hideyoshi Harashima(38), Hiroto Hatakeyama(15), Kentaro Kogure(13), Shiroh Futaki(8), Ikramy A. Khalil(6), Yu Sakurai(6), Yusuke Sato(6), Hiroshi Suzuki(6), Yuichi Sugiyama(6), Yuma Yamada(5), Mamoru Hyodo(5), Hiroki Tanaka(5), Kota Tange(5), Yuta Nakai(4), Motoi Oishi(3), Yukio Nagasaki(3), Hiroshi Kikuchi(3), Hiroyuki Kamiya(3), Rie Ito(3), Susumu Hama(3)