Hubert Hřebabecký

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry — Czech Republic

Medicine · Health Sciences

19h-index1.5kcitations174works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

HIV/AIDS drug development and treatment(59), Biochemical and Molecular Research(53), Carbohydrate Chemistry and Synthesis(42), DNA and Nucleic Acid Chemistry(34), Synthesis and Characterization of Heterocyclic Compounds(34)

Publications174 total

Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses
Antiviral Research·2020· 76 citedOpen Access
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer’s Disease
Journal of Medicinal Chemistry·2020· 45 citedOpen Access
Optimization of norbornyl‐based carbocyclic nucleoside analogs as cyclin‐dependent kinase 2 inhibitors
Journal of Molecular Recognition·2020· 4 cited
Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?
Bioorganic & Medicinal Chemistry Letters·2019· 6 cited
Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes
Organic & Biomolecular Chemistry·2018· 4 cited
Control of α/β Anomer Formation by a 2′,5′ Bridge: Toward Nucleoside Derivatives Locked in the South Conformation
The Journal of Organic Chemistry·2017· 3 cited
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology
Journal of Medicinal Chemistry·2016· 65 citedOpen Access
Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase
Antiviral Research·2016· 74 cited
9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction
Free Radical Biology and Medicine·2016· 27 citedOpen Access
Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors
Bioorganic & Medicinal Chemistry Letters·2016· 15 citedOpen Access
Polymerase-mediated incorporation of novel locked nucleic acids
Open Access CRIS of the University of Bern·2015Open Access
Nucleoside Inhibitors of Tick-Borne Encephalitis Virus
Antimicrobial Agents and Chemotherapy·2015· 90 citedOpen Access
The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design
Acta Crystallographica Section D Biological Crystallography·2015· 23 cited
A New Analogue of Locked Cyclohexane Nucleic Acids
Synthesis·2015
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action
Journal of Medicinal Chemistry·2015· 64 citedOpen Access
Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides
Organic & Biomolecular Chemistry·2015· 10 citedOpen Access
Synthesis of locked cyclohexene and cyclohexane nucleic acids (LCeNA and LCNA) with modified adenosine units
Organic & Biomolecular Chemistry·2015· 6 citedOpen Access
Norbornane-based nucleoside and nucleotide analogues locked in North conformation
Bioorganic & Medicinal Chemistry·2014· 19 citedOpen Access
Low-molecular-weight Inhibitors of Enterovirus Replication
Chemické listy·2014Open Access
From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus
Bioorganic & Medicinal Chemistry·2014· 18 cited
page 1 of 9Next →

Frequent Co-authors

Antonı́n Holý(25), Radim Nencka(19), Michal Šála(19), Martin Dračínský(14), Milan Dejmek(13), Milena Masojı́dková(11), Johan Neyts(11), Eliška Procházková(7), Ivan Votruba(6), Evžen Bouřa(6), Pavla Plačková(6), Armando M. De Palma(6), Pieter Leyssen(6), Helena Mertlíková‐Kaiserová(5), Jiri T. Beranek(5), Dominika Chalupská(4), Aleš Merta(3), Ivan Rosenberg(3), Miroslav Otmar(3), Erik De Clercq(3)