Anthony Q. Vu

University of California, San Diego — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index2.6kcitations26works5.52yr avg
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Research Topics

RNA Research and Splicing(14), Amyotrophic Lateral Sclerosis Research(12), Neurogenetic and Muscular Disorders Research(8), RNA modifications and cancer(5), RNA and protein synthesis mechanisms(4)

Publications26 total

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial
Nature Communications·2025· 4 citedOpen Access
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes
Neuron·2024· 7 citedOpen Access
Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis
Acta Neuropathologica·2022· 23 citedOpen Access
Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions
2022· 2 citedOpen Access
Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions
2022· 4 citedOpen Access
Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization
Journal of Clinical Investigation·2021· 64 citedOpen Access
Discovery and Functional Interrogation of the Virus and Host RNA Interactome of SARS-Cov-2 Proteins
SSRN Electronic Journal·2021· 2 citedOpen Access
Conserved metabolite regulation of stress granule assembly via AdoMet
The Journal of Cell Biology·2020· 20 citedOpen Access
Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors
Nature Methods·2020· 91 citedOpen Access
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages
Food Chemistry·2019· 78 citedOpen Access
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
Neuron·2019· 263 citedOpen Access
Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal
PLoS Genetics·2019· 21 citedOpen Access
Modulation of RNA-dependent interactions in stress granules prevents persistent TDP-43 accumulation in ALS/FTD
2018· 1 cited
Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages
2018· 2 citedOpen Access
Transcriptome–pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS
Acta Neuropathologica·2018· 102 citedOpen Access
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
Nature Communications·2016· 175 citedOpen Access
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
UKnowledge (University of Kentucky)·2016Open Access
Gene Expression Signatures of Sporadic ALS Motor Neuron Populations
2016· 26 cited
A Novel Splice-Site Mutation in ALS2 Establishes the Diagnosis of Juvenile Amyotrophic Lateral Sclerosis in a Family with Early Onset Anarthria and Generalized Dystonias
PLoS ONE·2014· 22 citedOpen Access
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
Nature Neuroscience·2012· 734 citedOpen Access
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Frequent Co-authors

G Yeo(22), Stephanie C. Huelga(7), Tiffany Y Liang(7), Kasey R. Hutt(6), John Ravits(6), Shawn Hoon(6), John P. Donohue(5), Lily Shiue(5), Ranjan Batra(5), Wenhao Jin(5), Manuel Ares(4), Jasmine R. Mueller(4), Michael W. Baughn(3), Katannya Kapeli(3), Sebastian Markmiller(3), William E. Dowdle(3), Joseph W. Lewcock(3), Balaji Sundararaman(3), Christopher B. Burge(3), Emily C. Wheeler(3)