John Ravits

University of California, San Diego — United States

Medicine · Health Sciences

58h-index18.1kcitations179works9.82yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Amyotrophic Lateral Sclerosis Research(134), Neurogenetic and Muscular Disorders Research(81), Parkinson's Disease Mechanisms and Treatments(23), Prion Diseases and Protein Misfolding(23), RNA Research and Splicing(18)

Publications175 total

TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins
Nature Cell Biology·2025· 2 citedOpen Access
Shared burden of ultra-rare genetic variants across a spectrum of motor neuron diseases
Translational Neurodegeneration·2025Open Access
TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Nature Neuroscience·2025· 10 citedOpen Access
Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis
Nature·2025· 6 citedOpen Access
RNA triggers chronic stress during neuronal aging
2025· 1 citedOpen Access
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress
Nature Neuroscience·2025· 22 citedOpen Access
Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics
The Lancet Neurology·2025· 29 citedOpen Access
CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis
Acta Neuropathologica Communications·2024· 5 citedOpen Access
CK1δ/e-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis
2024· 1 citedOpen Access
Acetylation of lysine 82 initiates TDP-43 nuclear loss of function by disrupting its nuclear import
2024· 3 cited
Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study
The Lancet Neurology·2024· 58 cited
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Nature·2024· 3 citedOpen Access
Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy
Acta Neuropathologica·2024· 5 citedOpen Access
CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
Neurobiology of Disease·2024· 13 citedOpen Access
Pathologic Changes in ELAVL3 Expression and Splicing Occur in TDP43 and Non-TDP43 Proteinopathies (P4-9.007)
Neurology·2024· 1 cited
Re-activation of neurogenic niches in aging brain
2024· 3 citedOpen Access
Misfolded <scp>alpha‐synuclein</scp> in amyotrophic lateral sclerosis: Implications for diagnosis and treatment
European Journal of Neurology·2024· 13 citedOpen Access
Re-Activation of Neurogenic Niches in Aging Brain
SSRN Electronic Journal·2024Open Access
Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations
2023· 3 citedOpen Access
Challenges of profiling motor neuron transcriptomes from human spinal cord
Neuron·2023· 20 cited
page 1 of 9Next →

Frequent Co-authors

Don W. Cleveland(10), Matthew B. Harms(9), Michael W. Baughn(9), Robert H. Baloh(8), Clotilde Lagier‐Tourenne(7), C. Frank Bennett(6), Richard J. Barohn(6), Shahram Saberi(6), Janet Cady(5), Frank Rigo(5), Sandrine Da Cruz(5), Melissa McAlonis‐Downes(5), Jennifer E. Stauffer(5), Pamela J. Shaw(4), Kasey R. Hutt(4), Shuo‐Chien Ling(4), G Yeo(4), Hiroshi Mitsumoto(4), Kevin Drenner(4), María José Gómez-Rodríguez(4)