Sandrine Da Cruz

VIB-KU Leuven Center for Brain & Disease Research — Belgium

Medicine · Health Sciences

31h-index7.0kcitations58works9.42yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(38), Neurogenetic and Muscular Disorders Research(21), Mitochondrial Function and Pathology(12), RNA Research and Splicing(10), Prion Diseases and Protein Misfolding(7)

Publications58 total

Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALS
2026Open Access
Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS
Nature Neuroscience·2025Open Access
Early brain-wide disruption of sleep microarchitecture in amyotrophic lateral sclerosis
Journal of Clinical Investigation·2025Open Access
RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights
Molecular Neurodegeneration·2025· 14 citedOpen Access
Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series
The Lancet·2025· 20 citedOpen Access
TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of function of TDP-43
Neuron·2025· 18 citedOpen Access
Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis.
2025· 1 citedOpen Access
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models
Science Translational Medicine·2025· 19 cited
Amyotrophic lateral sclerosis caused by FUS mutations: advances with broad implications
The Lancet Neurology·2025· 31 citedOpen Access
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS
Molecular Neurodegeneration·2024· 10 citedOpen Access
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS
2024Open Access
14-3-3θ, a novel player in TDP-43 pathophysiology: Implications for ALS/FTD
Neuron·2024Open Access
Lost in local translation: TDP-43 and FUS in axonal/neuromuscular junction maintenance and dysregulation in amyotrophic lateral sclerosis
Neuron·2023· 53 citedOpen Access
Current Methods In ALS Research
Journal of Visualized Experiments·2023Open Access
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation
Molecular Neurodegeneration·2021· 19 citedOpen Access
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB
Nature Neuroscience·2021· 65 citedOpen Access
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
Science·2021· 359 citedOpen Access
Additional file 3 of Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation
Figshare·2021Open Access
Additional file 3 of Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation
Figshare·2021Open Access
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation
2020· 3 citedOpen Access
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Frequent Co-authors

Don W. Cleveland(28), Melissa McAlonis‐Downes(18), Philippe A. Parone(15), Clotilde Lagier‐Tourenne(11), Shuo‐Chien Ling(9), Martin Maršala(9), Jean‐Claude Martinou(8), Christopher E. Shaw(7), John Ravits(6), Lino Tessarollo(6), Anne P. Vetto(6), Shuying Sun(5), Oleksandr Platoshyn(5), Anh Thu Bui(5), Sandra K. Lee(5), Luc Dupuis(5), Michael W. Baughn(4), C. Frank Bennett(4), Frank Rigo(4), Qiang Zhu(4)