Shuying Sun

Johns Hopkins University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index5.6kcitations77works6.12yr avg
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Research Topics

RNA Research and Splicing(30), Amyotrophic Lateral Sclerosis Research(25), Neurogenetic and Muscular Disorders Research(21), RNA modifications and cancer(14), Parkinson's Disease Mechanisms and Treatments(7)

Publications77 total

LINE1 RNA dysregulation impairs chromatin accessibility in C9ORF72- and TDP-43-linked ALS/FTD
2025Open Access
Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages
The Journal of Experimental Medicine·2025· 2 cited
Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons
2025· 5 citedOpen Access
DCPS modulates TDP-43 mediated neurodegeneration through P-body regulation
2025· 2 citedOpen Access
5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins
2025Open Access
PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD
Neuron·2025· 5 cited
Phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages
2025· 4 citedOpen Access
Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification
Cell Reports·2025· 7 citedOpen Access
RNA dysregulation in neurodegenerative diseases
The EMBO Journal·2025· 31 citedOpen Access
Statistical analysis of DNA methylation patterns of tumor suppressor genes in breast cancer
Epigenetics Insights·2025
Endosomal hyper-acidification via proton-activated chloride channel deletion in neurons impairs AMPA receptor endocytosis and LTD
2024Open Access
Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS
Neuron·2024· 23 citedOpen Access
Poly-GR repeats associated with ALS/FTD gene <i>C9ORF72</i> impair translation elongation and induce a ribotoxic stress response in neurons
Science Signaling·2024· 11 citedOpen Access
Pathological RNA-protein inclusions and dysregulated A-to-I RNA editing in synucleinopathies
Neuron·2024Open Access
Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia
2024· 3 citedOpen Access
Elevated nuclear TDP-43 induces constitutive exon skipping
Molecular Neurodegeneration·2024· 20 citedOpen Access
KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3
Science Advances·2024· 9 citedOpen Access
DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD
Experimental Neurology·2024· 7 citedOpen Access
KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3
2024Open Access
Abstract 2294 RNA dysfunction in C9ORF72-linked neurodegenerative diseases ALS and FTD
Journal of Biological Chemistry·2024Open Access
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Frequent Co-authors

Don W. Cleveland(10), Yini Li(9), Lindsey R. Hayes(8), Zhe Zhang(8), Yingzhi Ye(8), Adrian R. Krainer(7), Shuo‐Chien Ling(6), Melissa McAlonis‐Downes(6), Clotilde Lagier‐Tourenne(5), Kevin Drenner(5), Zuo‐Feng Zhang(5), Daoyuan Dong(5), Rong Wu(5), Sandrine Da Cruz(4), Shaopeng Wang(4), Zhaozhu Qiu(4), Shaopeng Wang(4), Jeffrey D. Rothstein(4), Bin Wu(4), Jonathan P. Ling(4)