Clotilde Lagier‐Tourenne

Broad Institute — United States

Medicine · Health Sciences

48h-index14.8kcitations93works16.32yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(52), Neurogenetic and Muscular Disorders Research(30), RNA Research and Splicing(23), Genetic Neurodegenerative Diseases(14), Mitochondrial Function and Pathology(12)

Publications93 total

Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes
2025Open Access
Stathmin-2 enhances motor axon regeneration after injury independent of its binding to tubulin
Proceedings of the National Academy of Sciences·2025· 11 citedOpen Access
Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders
2025· 6 cited
Pridopidine in Amyotrophic Lateral Sclerosis
JAMA·2025· 13 citedOpen Access
Verdiperstat in Amyotrophic Lateral Sclerosis
JAMA Neurology·2025· 9 citedOpen Access
Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis
JAMA Network Open·2025· 12 citedOpen Access
CNM-Au8 in Amyotrophic Lateral Sclerosis
JAMA·2025· 8 citedOpen Access
Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification
Nature Neuroscience·2025· 27 citedOpen Access
FUS controls muscle differentiation and structure through LLPS mediated recruitment of MEF2 and ETV5
2024· 2 citedOpen Access
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
Acta Neuropathologica·2024· 37 citedOpen Access
Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease
Acta Neuropathologica·2024· 54 citedOpen Access
Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations
2023· 3 citedOpen Access
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation
Nature Neuroscience·2023· 46 citedOpen Access
Aberrant splicing in Huntington’s disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification
2023· 15 citedOpen Access
iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons
Cell Reports·2023· 25 citedOpen Access
Mechanism of <i>STMN2</i> cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies
Science·2023· 231 citedOpen Access
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Neuron·2023· 108 citedOpen Access
Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies
Journal of Molecular Biology·2023· 7 citedOpen Access
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation
2022· 9 citedOpen Access
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of <i>C9orf72</i> disease
Proceedings of the National Academy of Sciences·2022· 8 citedOpen Access
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Frequent Co-authors

Don W. Cleveland(24), Shuo‐Chien Ling(10), G Yeo(9), C. Frank Bennett(8), John Ravits(8), Michael W. Baughn(8), Melissa McAlonis‐Downes(8), Magdalini Polymenidou(7), Jie Jiang(7), Leonard Petrucelli(7), Kevin Drenner(6), Ying Sun(6), Sandrine Da Cruz(6), Tania F. Gendron(6), Christopher E. Shaw(5), Jone López‐Erauskin(5), Frank Rigo(5), Shuying Sun(5), Jonathan W. Artates(5), Martin Maršala(5)