Marjolein J. Vliem

Utrecht University — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index957citations22works3.82yr avg
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Research Topics

Cellular Mechanics and Interactions(8), Hippo pathway signaling and YAP/TAZ(7), Microtubule and mitosis dynamics(4), Wnt/β-catenin signaling in development and cancer(4), Cell Adhesion Molecules Research(3)

Publications22 total

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state
Cell Reports·2025· 2 citedOpen Access
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
Science Signaling·2025· 4 cited
Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression
Gut·2025· 2 citedOpen Access
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding
2025
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer
The Journal of Pathology·2024· 11 citedOpen Access
Mechanical regulation of cell fate transitions underlying colorectal cancer metastasis formation
2023· 3 citedOpen Access
A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
Cell Reports·2022· 73 citedOpen Access
A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
2021· 5 citedOpen Access
An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity
The Journal of Cell Biology·2021· 34 citedOpen Access
Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions
Small GTPases·2018· 22 citedOpen Access
The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex.
Journal of Biological Chemistry·2016· 29 citedOpen Access
Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation
Molecular and Cellular Biology·2015· 86 citedOpen Access
The Small GTPase RALA Controls c-Jun N-terminal Kinase-mediated FOXO Activation by Regulation of a JIP1 Scaffold Complex
Journal of Biological Chemistry·2013· 35 citedOpen Access
Rap1 Can Bypass the FAK-Src-Paxillin Cascade to Induce Cell Spreading and Focal Adhesion Formation
PLoS ONE·2012· 17 citedOpen Access
Rap2A links intestinal cell polarity to brush border formation
Nature Cell Biology·2012· 105 cited
Role of Epac and protein kinase A in thyrotropin-induced gene expression in primary thyrocytes
Experimental Cell Research·2012· 6 cited
The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity
The Journal of Cell Biology·2011· 52 cited
Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins
Molecular and Cellular Biology·2010· 67 citedOpen Access
Cover Picture: 8‐pCPT‐2′‐O‐Me‐cAMP‐AM: An Improved Epac‐Selective cAMP Analogue (ChemBioChem 13/2008)
ChemBioChem·2008
8‐pCPT‐2′‐O‐Me‐cAMP‐AM: An Improved Epac‐Selective cAMP Analogue
ChemBioChem·2008· 115 cited
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Frequent Co-authors

Martijn Gloerich(12), Willem‐Jan Pannekoek(10), Johannes L. Bos(9), Holger Rehmann(7), Ronja M. Houtekamer(5), Jooske L. Monster(5), Bas Ponsioen(4), Matthijs R.H. Kooistra(4), Lars J S Kemp(4), Mirjam C. van der Net(4), Kees Jalink(3), Lisa Donker(3), Antoine Khalil(3), Frank Schwede(2), Jürgen Riedl(2), Hans‐Gottfried Genieser(2), Fried Zwartkruis(2), Hans Clevers(2), Helena Canever(2), Manuel Gómez‐González(2)