Frederic D. Bushman

University of Pennsylvania — United States

Immunology and Microbiology · Life Sciences

138h-index122.8kcitations766works3.82yr avg
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Research Topics

HIV Research and Treatment(171), CAR-T cell therapy research(152), HIV/AIDS drug development and treatment(120), CRISPR and Genetic Engineering(113), Virus-based gene therapy research(109)

Publications765 total

Delayed neurotoxicity, enterocolitis, and BCMA-CART-associated immune-related adverse events (CirAE)  are caused by CD4+ CAR T-cells
Blood·2025
Optimizing methods for virome analysis based on studies of a synthetic viral community
2025Open Access
Lung transplant for CF: Low lung bacterial burden and immune mediators in year one associate with CLAD development
Journal of Cystic Fibrosis·2025
Lentiviral vectors for hematopoietic stem cell gene therapy restore α-globin expression in α-thalassemia red blood cells
Cell Reports Medicine·2025Open Access
CD4+ T-Cells Mediate Immune-Related Adverse Events (CirAE) Following BCMA CAR-T Therapy
Clinical Lymphoma Myeloma & Leukemia·2025
An integrated enzymatic and computational pipeline for quantifying off-target base-editing
2025Open Access
Structures of Nucleotide-Bound Redondovirus Rep Protein Link Conformation and Function
2025Open Access
Pooled CAR-T screening in pig-tailed macaques identifies designs with enhanced proliferation, trafficking, and persistence
Blood·2025· 1 citedOpen Access
Preclinical quality, safety, and efficacy of a CGMP iPSC-derived myogenic progenitor product for the treatment of muscular dystrophies
Molecular Therapy·2025· 7 citedOpen Access
Antigenic Characterization of H1N1 Influenza Viruses That Circulated During the 2019–2020 Season in Philadelphia, Pennsylvania
Influenza and Other Respiratory Viruses·2025Open Access
Lentiviral gene therapy with reduced-intensity conditioning for sickle cell disease: a phase 1/2 trial
Nature Medicine·2025· 9 citedOpen Access
Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors
Journal of Molecular Biology·2025Open Access
Determining the Genetic Drivers of Diffuse Large B Cell Lymphoma 30 Years After Gamma Retroviral Gene Therapy for Severe Combined Immunodeficiency due to Adenosine Deaminase Deficiency
Journal of Human Immunity·2025Open Access
Abstract 3807: Validation of a functional genomics screen based on lentiviral integration site analysis reveals single-gene disruptions enhancing CAR19 T-cell effectiveness in preclinical models
Cancer Research·2025
Small molecule inhibition of SUMOylation increases expression from AAV vectors both during and after initial transduction in mice
Molecular Therapy·2025Open Access
Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease
Nature Communications·2025· 10 citedOpen Access
Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice
Nature Microbiology·2025· 4 citedOpen Access
Virolithopanspermia: Might viruses be transported in rocks through space?
PLoS Pathogens·2025· 1 citedOpen Access
Author response for "Antigenic Characterization of H1N1 Influenza Viruses That Circulated During the 2019–2020 Season in Philadelphia, Pennsylvania"
2025
Understanding the Molecular Mechanism of Redondovirus Rep in Rolling Circle Replication of the Redondoviral Genome
Structural Dynamics·2025Open Access
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Frequent Co-authors

Kyle Bittinger(12), Gary D. Wu(12), James D. Lewis(11), Rob Knight(10), Hongzhe Li(9), Christian Hoffmann(7), Rohini Sinha(7), Carl H. June(7), Dan Knights(6), Ronald G. Collman(6), Bruce L. Levine(6), Christopher L. Nobles(6), Catherine Lozupone(5), Emily S. Charlson(5), Joseph A. Fraietta(5), Irina Kulikovskaya(5), Simon F. Lacey(5), Scott T. Kelley(4), Robert N. Baldassano(4), Charles C. Berry(4)