Leah S. Torrie

University of Dundee — United Kingdom

Medicine · Health Sciences

22h-index2.3kcitations41works2.02yr avg
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Research Topics

Trypanosoma species research and implications(23), Research on Leishmaniasis Studies(19), Biochemical and Molecular Research(14), Enzyme function and inhibition(5), Computational Drug Discovery Methods(4)

Publications41 total

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease
Science Translational Medicine·2025· 2 citedOpen Access
Author response for "Structure-activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi"
2025
Structure–activity relationships of 1,5-dihydro-2 <i>H</i> -benzo[ <i>b</i> ][1,4]diazepine-2,4(3 <i>H</i> )-diones as inhibitors of <i>Trypanosoma cruzi</i>
RSC Medicinal Chemistry·2025Open Access
Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors
Journal of Biological Chemistry·2024· 6 citedOpen Access
Toolkit of Approaches To Support Target-Focused Drug Discovery for <i>Plasmodium falciparum</i> Lysyl tRNA Synthetase
ACS Infectious Diseases·2022· 22 citedOpen Access
Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease
Antimicrobial Agents and Chemotherapy·2021· 20 citedOpen Access
A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research
PLoS Biology·2021· 237 citedOpen Access
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
ACS Infectious Diseases·2020· 17 citedOpen Access
<i>Trypanosoma cruzi</i> Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment
Antimicrobial Agents and Chemotherapy·2019· 9 citedOpen Access
Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay
Antimicrobial Agents and Chemotherapy·2019· 42 citedOpen Access
<i>Burkholderia pseudomallei </i><scp>d</scp>‐alanine‐<scp>d</scp>‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target
FEBS Journal·2019· 8 citedOpen Access
Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase
PLoS ONE·2019· 8 citedOpen Access
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Proceedings of the National Academy of Sciences·2019· 132 citedOpen Access
Pharmacological Validation of <i>N</i>-Myristoyltransferase as a Drug Target in <i>Leishmania donovani</i>
ACS Infectious Diseases·2018· 68 citedOpen Access
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant <i>N</i> -Myristoyltransferase Inhibitors
Journal of Medicinal Chemistry·2018· 53 citedOpen Access
Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Nature Reviews Microbiology·2018· 3 citedOpen Access
Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a isopropyl methyl indole aryl sulphonamide ligand
2018
Design and Synthesis of Brain Penetrant Trypanocidal <i>N</i>-Myristoyltransferase Inhibitors
Journal of Medicinal Chemistry·2017· 20 citedOpen Access
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in <i>Leishmania donovani</i>
ACS Infectious Diseases·2017· 29 citedOpen Access
Erratum: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Nature Reviews Microbiology·2017· 32 citedOpen Access
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Frequent Co-authors

Ian H. Gilbert(24), Paul G. Wyatt(19), David A. Robinson(19), Kevin D. Read(17), Alan H. Fairlamb(14), Manu De Rycker(13), Julie A. Frearson(13), Ruth Brenk(13), Laste Stojanovski(12), David W. Gray(11), Stephen Brand(11), Irene Hallyburton(11), Susan Wyllie(10), Stuart P. McElroy(9), Michael A. J. Ferguson(8), Justin R. Harrison(8), Suzanne Norval(8), Sharon M. Shepherd(7), Victoria Smith(6), Daniel Spinks(6)