Irene Hallyburton

University of Dundee — United Kingdom

Medicine · Health Sciences

21h-index2.4kcitations48works0.02yr avg
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Research Topics

Trypanosoma species research and implications(16), Malaria Research and Control(14), Research on Leishmaniasis Studies(11), Computational Drug Discovery Methods(9), HIV/AIDS drug development and treatment(9)

Publications48 total

ResMAP—a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in <i>Plasmodium</i>
mBio·2024Open Access
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
Journal of Medicinal Chemistry·2023· 6 citedOpen Access
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as <i>Pf</i>eEF2
ChemMedChem·2022· 9 citedOpen Access
Toolkit of Approaches To Support Target-Focused Drug Discovery for <i>Plasmodium falciparum</i> Lysyl tRNA Synthetase
ACS Infectious Diseases·2022· 22 citedOpen Access
Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials
RSC Medicinal Chemistry·2022· 5 citedOpen Access
An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials
Journal of Medicinal Chemistry·2021· 19 citedOpen Access
Preparation, biological &amp; cheminformatics-based assessment of N2,N4-diphenylpyrimidine-2,4-diamine as potential Kinase-targeted antimalarials
Bioorganic & Medicinal Chemistry·2021· 10 cited
Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators
Bioorganic Chemistry·2021· 5 cited
From Seed to Root: the WeeCAIR Medicinal Garden
2021
CCDC 2032540: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Escaping from Flatland: Antimalarial Activity of sp<sup>3</sup>-Rich Bridged Pyrrolidine Derivatives
ACS Medicinal Chemistry Letters·2020· 19 citedOpen Access
An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials
2020· 1 citedOpen Access
An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials
2020· 1 citedOpen Access
Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials
Journal of Medicinal Chemistry·2020· 137 citedOpen Access
Translations: from laboratory to print studio: LifeSpace , University of Dundee
Discovery Research Portal (University of Dundee)·2020
Substituted Aminoacetamides as Novel Leads for Malaria Treatment
ChemMedChem·2019· 7 citedOpen Access
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Proceedings of the National Academy of Sciences·2019· 132 citedOpen Access
Pharmacological Validation of <i>N</i>-Myristoyltransferase as a Drug Target in <i>Leishmania donovani</i>
ACS Infectious Diseases·2018· 68 citedOpen Access
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant <i>N</i> -Myristoyltransferase Inhibitors
Journal of Medicinal Chemistry·2018· 53 citedOpen Access
Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a isopropyl methyl indole aryl sulphonamide ligand
2018
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Frequent Co-authors

Ian H. Gilbert(26), Julie A. Frearson(22), Kevin D. Read(22), Paul G. Wyatt(21), Laste Stojanovski(18), Alan H. Fairlamb(17), Suzanne Norval(16), David W. Gray(11), Leah S. Torrie(11), Neil R. Norcross(10), David A. Robinson(10), Beatriz Baragaña(9), Elizabeth A. Winzeler(9), Stephen Brand(9), Frederick R. C. Simeons(8), Jennifer Riley(8), Francisco‐Javier Gamo(8), Sergio Wittlin(8), Paul Willis(8), Ruth Brenk(8)