Letian Kuai

WuXi AppTec (China) — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.3kcitations40works4.02yr avg
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Research Topics

Chemical Synthesis and Analysis(17), Click Chemistry and Applications(8), Monoclonal and Polyclonal Antibodies Research(7), RNA and protein synthesis mechanisms(5), Protein Degradation and Inhibitors(5)

Publications40 total

The Influence of Single-Stranded or Double-Stranded DNA Tags on Ligand Binding Affinity in DNA-Encoded Libraries
Analytical Chemistry·2025· 1 cited
Van Leusen Imidazole Synthesis for One-Bead-One-Compound DNA-Encoded Libraries
Bioconjugate Chemistry·2025
Native Mass Spectrometry Facilitates Hit Validation in DNA‐Encoded Library Technology
Angewandte Chemie International Edition·2025· 5 citedOpen Access
Native Massenspektrometrie erleichtert die Hit‐Validierung in der DNA‐Encoded Library Technologie
Angewandte Chemie·2025Open Access
DNA-Compatible Huisgen [3 + 2] Cycloaddition of In Situ Formed Nitrile Oxides with Alkenes or Alkynes to Synthesize Isoxazolines or Isoxazoles
The Journal of Organic Chemistry·2025· 6 cited
Development of a DNA-encoded library screening method “DEL Zipper” to empower the study of RNA-targeted chemical matter
SLAS DISCOVERY·2024· 9 citedOpen Access
Development of a DNA-encoded library screening method DEL Zipper to empower the study of RNA-targeted chemical matter
2024Open Access
Highly Selective Novel Heme Oxygenase-1 Hits Found by DNA-Encoded Library Machine Learning beyond the DEL Chemical Space
ACS Medicinal Chemistry Letters·2024· 6 citedOpen Access
Highly Selective Novel Heme Oxygenase-1-Targeting Molecules Discovered by DNA-Encoded Library-Machine Learning Model beyond the DEL Chemical Space
2024· 2 citedOpen Access
DNA-Compatible Cyclization Reaction to Access 1,3,4-Oxadiazoles and 1,2,4-Triazoles
Organic Letters·2024· 11 cited
Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells
Nature Biomedical Engineering·2023· 24 cited
DELs enable the development of BRET probes for target engagement studies in cells
Cell chemical biology·2023· 9 citedOpen Access
DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor
ACS Medicinal Chemistry Letters·2023· 32 citedOpen Access
Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi
mBio·2023· 14 citedOpen Access
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4
Journal of Medicinal Chemistry·2022· 50 citedOpen Access
Assessment of AI-Based Protein Structure Prediction for the NLRP3 Target
Molecules·2022· 11 citedOpen Access
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection
SLAS DISCOVERY·2022· 42 citedOpen Access
DNA-encoded chemical libraries
Nature Reviews Methods Primers·2022· 157 cited
Assessment of AI-based Protein Structure Prediction for the NLRP3 Target
2021Open Access
Triaging of DNA-Encoded Library Selection Results by High-Throughput Resynthesis of DNA–Conjugate and Affinity Selection Mass Spectrometry
Bioconjugate Chemistry·2021· 41 citedOpen Access
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Frequent Co-authors

Wenji Su(26), Alexander L. Satz(18), Weiren Cui(15), Xiaodong Shi(8), Xuanjia Peng(8), Hongfang Yang(7), Stuart L. Schreiber(5), Yulong An(5), Yunyun He(5), Ke Li(5), Jason Deng(5), Zhongyao Ma(5), Andreas Gloger(4), Xiaojie Lu(4), Jörg Scheuermann(4), Huanan Wen(4), Yi Qu(4), Yanfang Shen(4), Shao‐En Ong(3), John L. Wood(3)