Katherine J. Seidl

Takeda (United States) — United States

Immunology and Microbiology · Life Sciences

14h-index2.5kcitations32works5.02yr avg
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Research Topics

Immunotherapy and Immune Responses(8), CAR-T cell therapy research(8), T-cell and B-cell Immunology(5), Immune Cell Function and Interaction(5), RNA Interference and Gene Delivery(4)

Publications32 total

Aging and Cancer—Inextricably Linked Across the Lifespan
Aging Cell·2025· 5 citedOpen Access
Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice
Frontiers in Immunology·2022· 9 citedOpen Access
Abstract 1525: Enhancing potency of antigen presenting cells via signal 2/3 mRNA engineering through Cell Squeeze® technology
Cancer Research·2021· 1 cited
Abstract 1523: Cell Squeeze® delivery of antigen-encoding mRNA enables human PBMCs to drive antigen-specific CD8+ T cell responses for diverse clinical applications
Cancer Research·2021
Abstract 1524: Peripheral blood mononuclear cells engineered via microfluidic Cell Squeeze® technology to generate APCs that drive mutant-KRas-specific CD8+ T cell responses
Cancer Research·2021· 1 cited
141 PBMC-based cancer vaccines generated with microfluidics squeezing demonstrate synergistic and durable tumor reduction in combination with PD1 checkpoint and FAP targeted IL-2 variants
Regular and Young Investigator Award Abstracts·2020· 3 citedOpen Access
169 Microfluidics cell squeezing enables human PBMCs as drivers of antigen-specific CD8 T responses across broad range of antigens for diverse clinical applications
Regular and Young Investigator Award Abstracts·2020· 4 citedOpen Access
165 Activating antigen carriers generated with microfluidics cell squeezing drive effective anti-tumor responses
Regular and Young Investigator Award Abstracts·2020· 2 citedOpen Access
170 Microfluidics cell squeezing enables potent cellular vaccines in murine models through direct cytosolic loading and direct CD8 T cell priming
Regular and Young Investigator Award Abstracts·2020· 2 citedOpen Access
Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes
Journal of Clinical Investigation·2018· 51 citedOpen Access
A Novel TGF-β2/Interleukin Receptor Signal Conversion Platform That Protects CAR/TCR T Cells from TGF-β2-Mediated Immune Suppression and Induces T Cell Supportive Signaling Networks
Blood·2017· 5 cited
Predominant VH genes expressed associated with distinctive antige
2016
TRIL Is Involved in Cytokine Production in the Brain following <i>Escherichia coli</i> Infection
The Journal of Immunology·2014· 32 citedOpen Access
Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease
Autoimmune Diseases·2014· 6 citedOpen Access
Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice
Arthritis & Rheumatism·2010· 74 cited
The novel and selective JAK3 inhibitor WYE-152038 is highly efficacious in a mouse model of rheumatoid arthritis
Cytokine·2009
TRIL is a novel modulator of TLR4 with enriched expression in the brain
Cytokine·2009
TRIL, a Functional Component of the TLR4 Signaling Complex, Highly Expressed in Brain
The Journal of Immunology·2009· 53 citedOpen Access
Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood
Journal of Biological Chemistry·2007· 76 citedOpen Access
Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions
Journal of Biological Chemistry·2004· 56 citedOpen Access
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Frequent Co-authors

Howard Bernstein(8), Scott Loughhead(7), Frederick W. Alt(6), Armon Sharei(6), Laurie A. Davidson(5), Joan C. Gorga(5), James E. Strickler(5), Robert E. Babine(5), David T. Weaver(5), Defne Yarar(5), JoAnn Sekiguchi(4), James D. Clark(4), Lih‐Ling Lin(4), Carolyne K. Smith(4), Amritha Ramakrishnan(4), Karen M. Frank(3), Gary Rathbun(3), Steve Tam(3), Cheryl Nickerson‐Nutter(3), Debra G. Goodwin(3)