Armon Sharei

SQZ Biotech (United States) — United States

Medicine · Health Sciences

17h-index2.9kcitations69works0.02yr avg
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Research Topics

CAR-T cell therapy research(29), Microfluidic and Bio-sensing Technologies(20), RNA Interference and Gene Delivery(19), Immunotherapy and Immune Responses(18), 3D Printing in Biomedical Research(14)

Publications69 total

A next generation immune cell engineering platform to create multifunctional cells using a silicon membrane-based delivery system 4591
The Journal of Immunology·2025Open Access
1027 A silicon membrane-based approach to deliver circular RNAs and engineer CAR-Ts with durable expression of membrane bound IL-2 and IL-12
Regular and Young Investigator Award Abstracts·2025Open Access
1017 A next generation immune cell engineering platform to create multifunctional cells using a silicon membrane-based delivery system
Regular and Young Investigator Award Abstracts·2025Open Access
A next generation cell engineering platform to create multifunctional cells using a silicon membrane-based delivery system
Cytotherapy·2025
Abstract 3160: Silicon membrane technology enables novel live-cell assays for screening impermeable compounds prior to medchem optimization
Cancer Research·2025
Abstract 5862: Combining circular RNA and a silicon membrane-based cell engineering approach to create CAR-Ts with membrane bound IL-2 and IL-12
Cancer Research·2025
A Highly Versatile Platform for Multiplexed Cell Engineering for Cancer Immunotherapy and Stem Cell Therapy
Blood·2024Open Access
350 A platform for multiplexed RNA-based and genomic cell engineering for cancer immunotherapy
Regular and Young Investigator Award Abstracts·2024Open Access
Abstract B046: Enhanced immune cell engineering utilizing a novel, effective intracellular delivery method for introduction of diverse cargo types
Cancer Immunology Research·2024
A PLATFORM FOR RNA-BASED AND GENOMIC CELL ENGINEERING: SIMPLIFYING MULTIPLEXED DELIVERY TO HUMAN PRIMARY IMMUNE AND STEM CELLS
Cytotherapy·2024
A new benchtop system for simple and versatile introduction of macromolecules into human lymphocytes and CD34+ cells by microfluidic squeezing
The Journal of Immunology·2023Open Access
Gene editing through microfluidic delivery
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·2023Open Access
Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors
Investigational New Drugs·2023· 6 citedOpen Access
Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ- PBMC-HPV) in HLA-A*02+ patients with HPV16+ Solid Tumors
Research Square (Research Square)·2022Open Access
224 Generation of cell therapies for diverse applications using microfluidic Cell Squeeze<sup>®</sup>manufacturing technology
Regular and Young Investigator Award Abstracts·2022Open Access
638 COMMANDER-001: a phase 1/2, first-in-human, multicenter, open label study of SQZ-eAPC-HPV as monotherapy and with pembrolizumab in patients with HPV16+ recurrent, locally advanced, or metastatic solid tumors (trial in progress)
Regular and Young Investigator Award Abstracts·2022Open Access
Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice
Frontiers in Immunology·2022· 9 citedOpen Access
Cell Squeeze: driving more effective CD8 T-cell activation through cytosolic antigen delivery
Immuno-Oncology Technology·2022· 12 citedOpen Access
Abstract 2853: Co-delivery of antigen-encoding mRNA and signal 2/3 mRNAs to PBMCs by Cell Squeeze® technology generates SQZ™ eAPCs that prime CD8+T cells in a humanized mouse model
Cancer Research·2022
Engineered RBCs Encapsulating Antigen Induce Multi-Modal Antigen-Specific Tolerance and Protect Against Type 1 Diabetes
Frontiers in Immunology·2022· 14 citedOpen Access
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Frequent Co-authors

Howard Bernstein(22), Klavs F. Jensen(20), Scott Loughhead(18), Róbert Langer(13), Shirley Mao(11), Andrea Adamo(9), Katarina Blagović(9), Defne Yarar(9), Jonathan B. Gilbert(8), Nahyun Cho(6), Matthew G. Booty(6), Carolyne K. Smith(6), Melissa Myint(6), Katherine J. Seidl(6), Devin Bridgen(5), Kelan A. Hlavaty(5), Emily Jackson(4), Tia DiTommaso(4), Jacquelyn Hanson(4), Megan Heimann(4)