Carolyne K. Smith

SQZ Biotech (United States) — United States

Immunology and Microbiology · Life Sciences

19h-index3.9kcitations38works0.02yr avg
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Research Topics

Neutrophil, Myeloperoxidase and Oxidative Mechanisms(11), Systemic Lupus Erythematosus Research(10), Atherosclerosis and Cardiovascular Diseases(10), Immunotherapy and Immune Responses(7), CAR-T cell therapy research(6)

Publications38 total

321 Single mRNA constructs encoding multiple linked antigens allow for a multiantigen-specific CD8<sup>+</sup> T cell response driven by SQZ<sup>®</sup> eAPCs
Regular and Young Investigator Award Abstracts·2022Open Access
Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice
Frontiers in Immunology·2022· 9 citedOpen Access
Abstract 2853: Co-delivery of antigen-encoding mRNA and signal 2/3 mRNAs to PBMCs by Cell Squeeze® technology generates SQZ™ eAPCs that prime CD8+T cells in a humanized mouse model
Cancer Research·2022
Microfluidic Squeezing Enables MHC Class I Antigen Presentation by Diverse Immune Cells to Elicit CD8+ T Cell Responses with Antitumor Activity
The Journal of Immunology·2022· 21 citedOpen Access
156 RBC-derived, activating antigen carriers (SQZ AACs) prime potent T cell responses and drive tumor regression in vivo
Regular and Young Investigator Award Abstracts·2021· 1 citedOpen Access
Abstract 1523: Cell Squeeze® delivery of antigen-encoding mRNA enables human PBMCs to drive antigen-specific CD8+ T cell responses for diverse clinical applications
Cancer Research·2021
Abstract 1524: Peripheral blood mononuclear cells engineered via microfluidic Cell Squeeze® technology to generate APCs that drive mutant-KRas-specific CD8+ T cell responses
Cancer Research·2021· 1 cited
169 Microfluidics cell squeezing enables human PBMCs as drivers of antigen-specific CD8 T responses across broad range of antigens for diverse clinical applications
Regular and Young Investigator Award Abstracts·2020· 4 citedOpen Access
Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus
Annals of the Rheumatic Diseases·2019· 154 citedOpen Access
The interplay between neutrophils and microbiota in cancer
Journal of Leukocyte Biology·2018· 20 cited
Abstract 4926: Gut microbiota regulates cisplatin mediated cachexia and systemic toxicity
Cancer Research·2017
Brief Report: Deficiency of Complement 1r Subcomponent in Early‐Onset Systemic Lupus Erythematosus: The Role of Disease‐Modifying Alleles in a Monogenic Disease
Arthritis & Rheumatology·2017· 44 citedOpen Access
IL-33R signaling in CD4+ T cells regulates intratumoral myeloid cell recruitment.
The Journal of Immunology·2017
Microbes and Cancer
Annual Review of Immunology·2017· 285 cited
Workshop Report: Modulation of Antitumor Immune Responses by Dietary and Microbial Metabolites
JNCI Journal of the National Cancer Institute·2017· 10 citedOpen Access
II-17 Lupus HDL promotes pro-inflammatory responses in macrophages through LOX1R binding and abrogation of ATF3 activity
Innate Immunity·2016Open Access
Lupus high-density lipoprotein induces proinflammatory responses in macrophages by binding lectin-like oxidised low-density lipoprotein receptor 1 and failing to promote activating transcription factor 3 activity
Annals of the Rheumatic Diseases·2016· 61 cited
Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction
Arthritis & Rheumatology·2016· 207 citedOpen Access
Brief Report: Vitamin D Deficiency Is Associated With Endothelial Dysfunction and Increases Type I Interferon Gene Expression in a Murine Model of Systemic Lupus Erythematosus
Arthritis & Rheumatology·2016· 36 citedOpen Access
269 Vitamin D Deficiency Promotes Vascular Damage and Disease Activity in a Murine Model of Systemic Lupus Erythematosus
Lara D. Veeken·2016Open Access
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Frequent Co-authors

Mariana J. Kaplan(17), Scott Loughhead(8), Howard Bernstein(7), Anuradha Vivekanandan‐Giri(6), Subramaniam Pennathur(6), Armon Sharei(6), Giorgio Trinchieri(5), Katarina Blagović(5), Sarfaraz Hasni(4), Emrah Ilker Ozay(4), Defne Yarar(4), Katherine J. Seidl(4), Michael F. Maloney(4), Carmelo Carmona‐Rivera(3), Wenpu Zhao(3), Martin P. Playford(3), Nehal N. Mehta(3), Christian Yee(3), Melissa Myint(3), Amritha Ramakrishnan(3)