Steven G. Grinnell

Memorial Sloan Kettering Cancer Center — United States

Neuroscience · Life Sciences

16h-index2.7kcitations31works0.72yr avg
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Research Topics

Neuropeptides and Animal Physiology(19), Receptor Mechanisms and Signaling(15), Pharmacological Receptor Mechanisms and Effects(11), Pain Mechanisms and Treatments(4), Cancer Genomics and Diagnostics(4)

Publications31 total

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu–Kappa Opioid Receptor Agonist Analgesic
ACS Chemical Neuroscience·2025· 2 cited
S3Mirror: Making Genomic Data Transfers Fast, Reliable, and Observable with DBOS
2025Open Access
S3Mirror: Making Genomic Data Transfers Fast, Reliable, and Observable with DBOS
arXiv (Cornell University)·2025Open Access
Plasma proteomic associations with genetics and health in the UK Biobank
Nature·2023· 1.3k citedOpen Access
A multi‐omic single cell sequencing approach to develop a <scp>CD8</scp> T cell specific gene signature for <scp>anti‐PD1</scp> response in solid tumors
International Journal of Cancer·2022· 5 cited
Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants
2022· 128 citedOpen Access
Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine
Neuropsychopharmacology·2021· 26 citedOpen Access
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
eLife·2021· 65 citedOpen Access
Author response: Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
2020Open Access
Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain
Cellular and Molecular Neurobiology·2020· 15 citedOpen Access
7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
ACS Central Science·2019· 198 citedOpen Access
Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
Neuron·2018· 70 citedOpen Access
The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
Neuropsychopharmacology·2017· 266 citedOpen Access
Extreme Vetting of Dopamine Receptor Oligomerization
2017· 4 cited
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
Journal of Medicinal Chemistry·2016· 298 citedOpen Access
Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants
Synapse·2016· 49 citedOpen Access
Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS
Proceedings of the National Academy of Sciences·2016· 34 citedOpen Access
A novel opioid for photoaffinity labeling opioid receptor complexes in natively‐expressing tissues
The FASEB Journal·2015
Endomorphins and DAMGO Utilize Different Mechanisms to Produce Analgesia
The FASEB Journal·2015
Mild, Pd-catalyzed stannylation of radioiodination targets
Bioorganic & Medicinal Chemistry Letters·2015· 17 cited
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Frequent Co-authors

Gavril W. Pasternak(21), Susruta Majumdar(19), Ying‐Xian Pan(12), Valerie Le Rouzic(10), John E. Pintar(9), András Váradi(7), Michael Ansonoff(7), Jonathan A. Javitch(7), Joan Subrath(6), Amanda Hunkele(5), Rajendra Uprety(5), Gina F. Marrone(4), Ankita Narayan(4), Shainnel O. Eans(4), Jin Xu(4), Jay P. McLaughlin(4), Grace C. Rossi(4), Maxim Burgman(3), Melissa Nelson(3), Saheem A. Zaidi(3)