Joan Subrath

Memorial Sloan Kettering Cancer Center — United States

Neuroscience · Life Sciences

13h-index683citations18works1.02yr avg
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Research Topics

Neuropeptides and Animal Physiology(9), Receptor Mechanisms and Signaling(7), Pharmacological Receptor Mechanisms and Effects(6), Protein Kinase Regulation and GTPase Signaling(5), Multicomponent Synthesis of Heterocycles(3)

Publications18 total

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu–Kappa Opioid Receptor Agonist Analgesic
ACS Chemical Neuroscience·2025· 2 cited
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
UNC Libraries·2024Open Access
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
eLife·2021· 65 citedOpen Access
Author response: Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
2020Open Access
Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain
Cellular and Molecular Neurobiology·2020· 15 citedOpen Access
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
Journal of Medicinal Chemistry·2016· 298 citedOpen Access
Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior
ACS Chemical Neuroscience·2015· 60 cited
Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction
ACS Chemical Neuroscience·2015· 50 citedOpen Access
ChemInform Abstract: Three‐Component Coupling Approach for the Synthesis of Diverse Heterocycles Utilizing Reactive Nitrilium Trapping.
ChemInform·2014
Three-Component Coupling Approach for the Synthesis of Diverse Heterocycles Utilizing Reactive Nitrilium Trapping
Organic Letters·2014· 23 citedOpen Access
CCDC 983004: Experimental Crystal Structure Determination
The Cambridge Structural Database·2014Open Access
Synthesis and Evaluation of Aryl-Naloxamide Opiate Analgesics Targeting Truncated Exon 11-Associated μ Opioid Receptor (MOR-1) Splice Variants
Journal of Medicinal Chemistry·2012· 50 citedOpen Access
Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCθ inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 14 citedOpen Access
Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 27 citedOpen Access
First generation 5-vinyl-3-pyridinecarbonitrile PKCθ inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 23 citedOpen Access
C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCθ inhibitors: Part II
Bioorganic & Medicinal Chemistry Letters·2009· 17 cited
C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCθ inhibitors: Part I
Bioorganic & Medicinal Chemistry Letters·2009· 18 citedOpen Access
Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCθ inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 21 citedOpen Access

Frequent Co-authors

Susruta Majumdar(12), András Váradi(11), Gavril W. Pasternak(11), Valerie Le Rouzic(7), Amanda Hunkele(7), Steven G. Grinnell(6), Ying‐Xian Pan(6), Travis C. Palmer(5), Shainnel O. Eans(5), Jay P. McLaughlin(5), Rajendra Uprety(5), Diane H. Boschelli(5), Biqi Wu(5), Xiaoke Yang(5), Agnes Brennan(5), Divya Chaudhary(5), Vsevolod Katritch(4), D.G. Afonin(4), Julie Lee(4), Gina F. Marrone(3)