Valerie Le Rouzic

Memorial Sloan Kettering Cancer Center — United States

Neuroscience · Life Sciences

17h-index1.3kcitations30works2.02yr avg
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Research Topics

Neuropeptides and Animal Physiology(18), Receptor Mechanisms and Signaling(12), Pharmacological Receptor Mechanisms and Effects(11), Alkaloids: synthesis and pharmacology(8), Traditional and Medicinal Uses of Annonaceae(5)

Publications30 total

Combined endurance and resistance exercise training alters the spatial transcriptome of skeletal muscle in young adults
iScience·2025· 3 citedOpen Access
Synthesis and Pharmacology of a Morphinan-Derived Dual Mu–Kappa Opioid Receptor Agonist Analgesic
ACS Chemical Neuroscience·2025· 2 cited
Combined aerobic and resistance exercise training alters the spatial transcriptome of skeletal muscle in young adults
2024· 1 citedOpen Access
207-OR: Myostatin Inhibition Synergizes with GLP-1R Agonism to Accelerate Weight Loss in Male, Obese Nonhuman Primates
Diabetes·2023· 10 cited
Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Cell stem cell·2023· 42 citedOpen Access
Oxidative Metabolism as a Modulator of Kratom’s Biological Actions
Journal of Medicinal Chemistry·2021· 54 citedOpen Access
Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom
ACS Chemical Neuroscience·2021· 36 citedOpen Access
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
eLife·2021· 65 citedOpen Access
Author response: Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
2020Open Access
Synthesis and Pharmacology of a Novel μ–δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template
Journal of Medicinal Chemistry·2020· 30 citedOpen Access
Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine
Molecular Pharmacology·2019· 15 citedOpen Access
7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
ACS Central Science·2019· 198 citedOpen Access
7-Hydroxymitragynine is an Active Metabolite of Mitragynine and a Key Mediator of its Analgesic Effects
2019· 5 citedOpen Access
7-Hydroxymitragynine is an Active Metabolite of Mitragynine and a Key Mediator of its Analgesic Effects
2019Open Access
Pharmacological Characterization of Levorphanol, a G-Protein Biased Opioid Analgesic
Anesthesia & Analgesia·2018· 25 citedOpen Access
Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo
JCI Insight·2017· 20 citedOpen Access
Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace
Neuropharmacology·2017· 90 cited
Genetic dissociation of morphine analgesia from hyperalgesia in mice
Psychopharmacology·2017· 21 citedOpen Access
Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception
MedChemComm·2016· 8 citedOpen Access
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
Journal of Medicinal Chemistry·2016· 298 citedOpen Access
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Frequent Co-authors

Gavril W. Pasternak(25), Susruta Majumdar(22), Ying‐Xian Pan(16), Amanda Hunkele(11), András Váradi(10), Steven G. Grinnell(10), Rajendra Uprety(10), Jin Xu(8), Michael Ansonoff(8), John E. Pintar(8), Joan Subrath(7), Shainnel O. Eans(7), Jay P. McLaughlin(7), Gina F. Marrone(6), Jonathan A. Javitch(5), Bryan L. Roth(5), Tao Che(5), Andrew C. Kruegel(4), Dalibor Sameš(4), Abdullah Allaoa(4)