Wai N. Chan

GlaxoSmithKline (United Kingdom) — United Kingdom

Neuroscience · Life Sciences

10h-index496citations17works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(7), Epilepsy research and treatment(4), Ion channel regulation and function(3), Molecular Sensors and Ion Detection(3), Malaria Research and Control(2)

Publications17 total

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor
Bioorganic & Medicinal Chemistry Letters·2001· 165 citedOpen Access
Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement
Psychopharmacology·2001· 93 cited
Use of the radioligand [125I]-SB-217644 in the characterisation and solubilisation of the novel binding site for the anticonvulsant SB-204269 in rat brain membranes and cell lines
Neuropharmacology·2000· 3 cited
Evaluation of a Series of Anticonvulsant 1,2,3,4-Tetrahydroisoquinolinyl-benzamides
Bioorganic & Medicinal Chemistry·2000· 10 cited
ChemInform Abstract: Identification of (‐)‐cis‐6‐Acetyl‐4S‐ (3‐chloro‐4‐fluorobenzoylamino)‐3,4‐dihydro‐2,2‐dimethyl‐2H‐benzo [b]pyran‐3S‐ol (I) as a Potential Antimigraine Agent.
ChemInform·1999
ChemInform Abstract: Identification of a Series of 1,2,3,4‐Tetrahydroisoquinolinyl Benzamides with Potential Anticonvulsant Activity.
ChemInform·1999
Identification of (−)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent
Bioorganic & Medicinal Chemistry Letters·1999· 54 citedOpen Access
Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity
Bioorganic & Medicinal Chemistry Letters·1998· 16 cited
Characterization of the binding of [<sup>3</sup>H]‐SB‐204269, a radiolabelled form of the new anticonvulsant SB‐204269, to a novel binding site in rat brain membranes
British Journal of Pharmacology·1997· 36 citedOpen Access
Profile of SB‐204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures
British Journal of Pharmacology·1997· 46 citedOpen Access
Conformational preference of the 6-acetyl group in novel anticonvulsant trans 4S-benzamido-benzo[b]pyran-3R-ols
Bioorganic & Medicinal Chemistry Letters·1997· 4 cited
ChemInform Abstract: Synthesis of Novel trans‐4‐(Substituted‐benzamido)‐3,4‐dihydro‐2H‐ benzo(b)pyran‐3‐ol Derivatives as Potential Anticonvulsant Agents with a Distinctive Binding Profile.
ChemInform·1997· 1 cited
The novel anticonvulsant SB 204269 binds to a stereospecific site in the mouse brain
European Journal of Pharmacology·1996· 10 cited
ChemInform Abstract: Stereochemical Preferences and Requirement for the 3‐Hydroxyl Group in Novel Anticonvulsant 4‐Fluorobenzoylamino Benzopyrans.
ChemInform·1996
Synthesis of Novel <i>trans</i>-4-(Substituted-benzamido)-3,4-dihydro-2<i>H</i>-benzo[<i>b</i>]pyran-3-ol Derivatives as Potential Anticonvulsant Agents with a Distinctive Binding Profile
Journal of Medicinal Chemistry·1996· 28 cited
Stereochemical preferences and requirement for the 3-hydroxyl group in novel anticonvulsant 4-fluorobenzoylamino benzopyrans
Bioorganic & Medicinal Chemistry Letters·1995· 10 cited
Stereochemical differentiation of anticonvulsant and antihypertensive effects in 4-(fluorobenzoylamino)-benzopyrans
Bioorganic & Medicinal Chemistry Letters·1995· 20 cited

Frequent Co-authors

Tania O. Stean(13), Neil Upton(12), Hugh J. Herdon(12), Michael S. Hadley(10), John Evans(10), Mervyn Thompson(10), Jeffrey C. Jerman(8), Antonio Vong(6), Helen K.A. Morgan(3), Geoffrey Stemp(3), John D. Harling(3), Barry S. Orlek(3), Robert W. Ward(3), M. THOMPSON(3), N. Upton(3), Amanda Johns(2), Stephen Brough(2), Darren Smart(2), Graham J. Riley(2), Jeff Jerman(2)