Miguel M. Lopes

University of Coimbra — Portugal

Neuroscience · Life Sciences

5h-index68citations19works1.12yr avg
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Research Topics

Genetic Neurodegenerative Diseases(11), Mitochondrial Function and Pathology(4), Virus-based gene therapy research(3), Parkinson's Disease Mechanisms and Treatments(2), Muscle Physiology and Disorders(2)

Publications19 total

Extracellular vesicles-associated AAVs for the treatment of Machado-Joseph disease
Molecular Therapy·2025· 1 citedOpen Access
rAAV-Delivered Bicistronic Artificial microRNAs for Allele-Specific Silencing Improve Motor and Molecular Outcomes in Spinocerebellar Ataxia Type 3
2025Open Access
AAV-mediated allele-specific silencing alleviates neuropathology in a novel non-human primate model of Spinocerebellar ataxia type 3
2025Open Access
Differential impact of mutant Ataxin-3 in hindbrain regions: further evidence of white matter loss as a core pathological feature
Experimental Neurology·2025· 1 citedOpen Access
Spinocerebellar ataxia type 3: from pathogenesis to promising therapeutics
Trends in Molecular Medicine·2025· 1 cited
Gene Editing for <i>ATXN3</i> Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity
2025
JoVE Video Dataset
2024Open Access
Isolation of Adeno-associated Viral Vectors Through a Single-step and Semi-automated Heparin Affinity Chromatography Protocol
Journal of Visualized Experiments·2024· 6 citedOpen Access
Viral-based animal models in polyglutamine disorders
Brain·2024· 4 citedOpen Access
Data Driven Approach to Support the Design of Road Safety Plans in Portuguese Municipalities
Lecture notes in business information processing·2024
Refractory Shock in a Newborn: The Diagnostic Challenge of Panhypopituitarism
Pediatric Oncall·2024Open Access
Differential Impact of Mutant Ataxin-3 Expression in Different Hindbrain Regions
SSRN Electronic Journal·2024Open Access
Isolation of Biologically Active Extracellular Vesicles-Associated AAVs for Gene Delivery to the Brain by Size Exclusion Chromatography
2023· 1 citedOpen Access
Isolation of Biologically Active Extracellular Vesicles-Associated AAVs for Gene Delivery to the Brain by Size Exclusion Chromatography
2023· 1 citedOpen Access
A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification
Gene Therapy·2022· 10 cited
miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3
Nucleic Acid Therapeutics·2021· 22 citedOpen Access
ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease
Molecular Therapy·2021· 14 citedOpen Access
Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease
Journal of Molecular Diagnostics·2020· 7 cited
AAV-Based Tools For The Development Of Cellular and Animal Models of Machado-Joseph Disease
Estudo Geral (Universidad de Coimbra)·2019

Frequent Co-authors

Luís Pereira de Almeida(15), Rui Jorge Nobre(14), Carina Henriques(11), Diana D Lobo(10), Sara Lopes(9), Ana Carolina da Silva(5), Sónia Duarte(4), Romina Aron Badin(4), David Rufino‐Ramos(4), Kevin Leandro(4), Magda M. Santana(4), Dina Pereira(3), Luísa Cortes(3), Philippe Hantraye(3), Laetitia S. Gaspar(3), Rafael Baganha(3), Casey A. Maguire(3), Ana Rita Fernandes(3), Ana C. Silva(2), Ana Vasconcelos‐Ferreira(2)