Didier Rotticci

AstraZeneca (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.0kcitations21works0.02yr avg
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Research Topics

Enzyme Catalysis and Immobilization(15), Analytical Chemistry and Chromatography(10), Microbial Metabolic Engineering and Bioproduction(7), Alzheimer's disease research and treatments(3), Cholinesterase and Neurodegenerative Diseases(3)

Publications21 total

Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides
Journal of Medicinal Chemistry·2012· 98 citedOpen Access
Potent and orally efficacious benzothiazole amides as TRPV1 antagonists
Bioorganic & Medicinal Chemistry Letters·2012· 4 citedOpen Access
First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms
Journal of Biological Chemistry·2012· 74 citedOpen Access
Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ‐Secretase Inhibitors
ChemMedChem·2012· 86 cited
Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy
Bioorganic & Medicinal Chemistry Letters·2012· 48 citedOpen Access
Preparation of imidazolyl-pyrimidine derivatives as GSK3 inhibitors.
2008
Candida antarctica Lipase B: A Tool for the Preparation of Optically Active Alcohols
Humana Press eBooks·2003· 15 cited
ChemInform Abstract: Candida Antarctica Lipase B — A Tool for the Preparation of Optically Active Alcohols
ChemInform·2001· 2 cited
Improved Enantioselectivity of a Lipase by Rational Protein Engineering
ChemBioChem·2001· 125 cited
Rational design of enantioselective enzymes requires considerations of entropy
Protein Science·2001· 71 citedOpen Access
Resolution of an Iridoid Synthon, Gastrolactol, by Means of Dynamic Acetylation and Lipase-Catalyzed Alcoholysis
The Journal of Organic Chemistry·2001· 16 cited
ChemInform Abstract: Mass Transport Limitations Reduce the Effective Stereospecificity in Enzyme‐Catalyzed Kinetic Resolution.
ChemInform·2000
Mass Transport Limitations Reduce the Effective Stereospecificity in Enzyme-Catalyzed Kinetic Resolution
Organic Letters·2000· 48 cited
Understanding and engineering the enantioselectivity of candida antarctica lipase b towards sec-alcohols
KTH Publication Database DiVA (KTH Royal Institute of Technology)·2000· 13 citedOpen Access
An active-site titration method for lipases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2000· 59 cited
Molecular recognition of sec-alcohol enantiomers by Candida antarctica lipase B
Journal of Molecular Catalysis B Enzymatic·1998· 111 cited
Chiral Recognition Of Alcohol Enantiomers In Acyl Transfer Reactions Catalysed By<i>Candida Antarctica</i>Lipase B
Biocatalysis and Biotransformation·1998· 106 cited
ChemInform Abstract: Enantiomerically Enriched Bifunctional sec‐Alcohols Prepared by Candida antarctica Lipase B Catalysis. Evidence of Non‐Steric Interactions.
ChemInform·1997
Enantiomerically enriched bifunctional sec-alcohols prepared by Candida antarctica lipase B catalysis. Evidence of non-steric interactions
Tetrahedron Asymmetry·1997· 55 cited
ChemInform Abstract: Candida antarctica Lipase B Catalyzed Kinetic Resolutions: Substrate Structure Requirements for the Preparation of Enantiomerically Enriched Secondary Alkanols.
ChemInform·1995
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Frequent Co-authors

Karl Hult(13), Torbjörn Norin(10), Christian Orrenius(6), Stefan von Berg(4), Karin Kolmodin(3), Jörg Holenz(3), Jenny Ottosson(3), Johanna C. Rotticci‐Mulder(2), Niklas Öhrner(2), Britt‐Marie Swahn(2), Johan Lindström(2), Marie Sundström(2), Jacob Kihlström(2), Lise‐Lotte Olsson(2), Juliette Janson(2), Biljana Georgievska(2), Johanna Fälting(2), Fernando W. Sehgelmeble(2), Susanne Rosqvist(2), Susanne Gustavsson(2)