Susanne Gustavsson

AstraZeneca (Sweden) — Sweden

Immunology and Microbiology · Life Sciences

12h-index910citations20works1.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

T-cell and B-cell Immunology(6), Alzheimer's disease research and treatments(6), Computational Drug Discovery Methods(5), Lysosomal Storage Disorders Research(4), Monoclonal and Polyclonal Antibodies Research(4)

Publications20 total

MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non‐clinical species and Alzheimer's disease patients
Alzheimer s & Dementia·2024· 1 citedOpen Access
Limited value of sputum culture to guide antibiotic treatment in a Danish emergency department.
PubMed·2020· 10 cited
Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice
Molecular Genetics and Metabolism Reports·2019· 22 citedOpen Access
Robust LC–MS/MS Methods for Analysis of Heparan Sulfate Levels in CSF and Brain for Application in Studies of MPS IIIA
Bioanalysis·2019· 9 cited
Behavioral and histological hallmarks of a mucopolysaccharidosis type IIIA mouse model
Molecular Genetics and Metabolism·2019
Therapeutic correction of central nervous system pathology by intravenously administered chemically modified sulfamidase in a mouse model of mucopolysaccharidosis type IIIA
Molecular Genetics and Metabolism·2018
Revisiting the peripheral sink hypothesis: inhibiting <scp>BACE</scp>1 activity in the periphery does not alter β‐amyloid levels in the <scp>CNS</scp>
Journal of Neurochemistry·2014· 44 cited
Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy
Journal of Neuroscience·2012· 44 citedOpen Access
Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease
Journal of Biological Chemistry·2012· 134 citedOpen Access
P1‐241: <i>In vivo</i> reduction of beta‐amyloid peptides in the brain of Tg2576 mice after oral administration of a novel BACE1 inhibitor
Alzheimer s & Dementia·2012Open Access
Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ‐Secretase Inhibitors
ChemMedChem·2012· 86 cited
Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy
Bioorganic & Medicinal Chemistry Letters·2012· 48 citedOpen Access
2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation
Journal of Biological Chemistry·2011· 158 citedOpen Access
Restoration of the Antibody Response to IgE/Antigen Complexes in CD23-Deficient Mice by CD23+ Spleen or Bone Marrow Cells
The Journal of Immunology·2000· 46 citedOpen Access
Importance of CD23 for Collagen-Induced Arthritis: Delayed Onset and Reduced Severity in CD23-Deficient Mice
The Journal of Immunology·1999· 27 citedOpen Access
Efficient IgG-mediated suppression of primary antibody responses in Fcγ receptor-deficient mice
Proceedings of the National Academy of Sciences·1999· 149 citedOpen Access
Impaired Antibody Responses in H-2Ab Mice
The Journal of Immunology·1998· 25 cited
The role of CD21 and CD23 in immune responses
[Uppsala University] , Distributor, Almqvist & Wiksell International eBooks·1996· 1 cited
Antibody Feedback Regulation in MRL/lpr Mice
Journal of Autoimmunity·1993· 4 cited
<i>In vivo</i> enhancement of the specific antibody response via the low‐affinity receptor for IgE
European Journal of Immunology·1993· 102 cited

Frequent Co-authors

Birgitta Heyman(6), Susanna Eketjäll(4), Juliette Janson(4), Stefan von Berg(4), Johanna Fälting(4), Karin Kolmodin(3), Johan Lundkvist(3), Samuel Svensson(3), Sara Wernersson(2), Fredrik Jeppsson(2), Sofia Karlström(2), Lise‐Lotte Olsson(2), Britt‐Marie Swahn(2), Tjerk Bueters(2), Fernando W. Sehgelmeble(2), Susanne Rosqvist(2), Jörg Holenz(2), Didier Rotticci(2), Per I. Arvidsson(2), Biljana Georgievska(2)