Heike Grassmé

University of Duisburg-Essen — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

44h-index8.0kcitations87works2.62yr avg
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Research Topics

Sphingolipid Metabolism and Signaling(50), Lipid Membrane Structure and Behavior(30), Cystic Fibrosis Research Advances(19), Bacterial biofilms and quorum sensing(12), Erythrocyte Function and Pathophysiology(11)

Publications87 total

Immune activation and response dynamics of human <scp>iPSC</scp> ‐derived macrophages in tuberculosis infection models
Clinical & Translational Immunology·2026Open Access
Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections
Journal of Molecular Medicine·2025· 1 citedOpen Access
Sphingosine-mediated death of <i>Pseudomonas aeruginosa</i> involves degradation of cardiolipin by the maintenance of outer lipid asymmetry system
Infection and Immunity·2025· 1 citedOpen Access
Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice
Tuberculosis·2024· 6 citedOpen Access
Sphingosine kills intracellular <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>
Pathogens and Disease·2024· 5 citedOpen Access
Reduced Sphingosine in Cystic Fibrosis Increases Susceptibility to Mycobacterium abscessus Infections
International Journal of Molecular Sciences·2023· 9 citedOpen Access
The Anti-Infectious Role of Sphingosine in Microbial Diseases
Cells·2021· 38 citedOpen Access
Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D
Cells·2020· 12 citedOpen Access
Acid Sphingomyelinase-Ceramide System in Bacterial Infections
Cellular Physiology and Biochemistry·2019· 40 citedOpen Access
The function of sphingomyelinases in mycobacterial infections
Biological Chemistry·2018· 9 cited
Sphingolipids as targets for inhalation treatment of cystic fibrosis
Advanced Drug Delivery Reviews·2018· 36 cited
Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin
Cellular Physiology and Biochemistry·2018· 16 citedOpen Access
Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide
Infection and Immunity·2017· 60 citedOpen Access
Regulation of <i>Staphylococcus aureus</i> Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase
Antioxidants and Redox Signaling·2017· 40 citedOpen Access
β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections
Cell Host & Microbe·2017· 100 citedOpen Access
Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia
Infection and Immunity·2017· 47 citedOpen Access
Crosstalk Between Sphingomyelinases and Reactive Oxygen Species in Mycobacterial Infection
Antioxidants and Redox Signaling·2017· 12 cited
Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System
Neurosignals·2016· 20 citedOpen Access
Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide
Cellular Physiology and Biochemistry·2016· 36 citedOpen Access
Role of Janus-Kinases in Major Depressive Disorder
Neurosignals·2016· 24 citedOpen Access
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Frequent Co-authors

Erich Gulbins(47), Florian Läng(12), Katrin Anne Becker(12), Andrea Riehle(11), Richard Kolesnick(6), Barbara Wilker(6), Michael Weller(6), Verena Jendrossek(6), Joachim Riethmüller(5), Klaus Ferlinz(5), Aaron P. Seitz(5), Aida Cremesti(4), Birgit Brenner(4), Alexander Carpinteiro(4), Michael J. Edwards(4), Yang Zhang(4), Yuqing Wu(4), Heinz Schwarz(3), Konrad Sandhoff(3), Gabriele von Kürthy(3)