Michael J. Edwards

University of Duisburg-Essen — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index4.0kcitations84works2.02yr avg
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Research Topics

Breast Cancer Treatment Studies(30), Breast Lesions and Carcinomas(25), Sphingolipid Metabolism and Signaling(20), Breast Implant and Reconstruction(17), Immune Response and Inflammation(9)

Publications84 total

Sphingosine Prevents Rhinoviral Infections
International Journal of Molecular Sciences·2024· 2 citedOpen Access
Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo
Cell Death and Disease·2022· 27 citedOpen Access
Molecular targets of endothelial phosphatidic acid regulating major depressive disorder
Journal of Neurochemistry·2022· 6 citedOpen Access
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
Journal of Molecular Medicine·2022· 28 citedOpen Access
Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice
Journal of Biological Chemistry·2022· 42 citedOpen Access
Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma
2021Open Access
Voltage-Gated Potassium Channels as Regulators of Cell Death
Frontiers in Cell and Developmental Biology·2020· 86 citedOpen Access
Therapeutic Inhaled Sphingosine for Treating Lung Infection in a Mouse Model of Critical Illness
Cellular Physiology and Biochemistry·2020· 3 citedOpen Access
Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family
Redox Biology·2020· 37 citedOpen Access
Abstract 2742: The role and mechanism of voltage-gated potassium channel, Kv1.3, in pancreatic ductal adenocarcinoma (PDAC)
Cancer Research·2020
Inhibition of Acid Sphingomyelinase Blocks Infection with SARS-CoV-2
SSRN Electronic Journal·2020· 3 citedOpen Access
Role of Sphingolipids in Bacterial Infections
2020· 1 cited
Role of Sphingolipids in Bacterial Infections
2018
Sphingolipids and Innate Immunity: A New Approach to Infection in the Post-Antibiotic Era?
Surgical Infections·2018· 17 cited
Comparison of the immunomodulatory and epigenetic regulatory effects of natural estrogen 17-β estradiol and its synthetic analog 17α-ethinyl estradiol in NZB/WF1 mice
The Journal of Immunology·2018
REVÊTEMENTS DE SPHINGOLIPIDE ET PROCÉDÉ DE FABRICATION DE REVÊTEMENTS DE SPHINGOLIPIDE EFFICACES POUR INHIBER LA FORMATION DE BIOFILM
2017
Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic
Biochimie·2017· 33 cited
Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes
PLoS ONE·2016· 31 citedOpen Access
Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System
Neurosignals·2016· 20 citedOpen Access
Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide
Cellular Physiology and Biochemistry·2016· 36 citedOpen Access
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Frequent Co-authors

Erich Gulbins(18), Kelly M. McMasters(17), Alex B. Lentsch(12), Sandra L. Wong(9), Celia Chao(8), Katrin Anne Becker(7), Heike Grassmé(7), Todd M. Tuttle(6), David J. Carlson(6), Burkhard Kleuser(6), Barbara Wilker(6), Anees B. Chagpar(6), Diana Simpson(6), Johannes Kornhuber(6), R. Dirk Noyes(5), Rebecca Schuster(5), Matthias Soddemann(5), Richard S. Hoehn(5), Peter S. Turk(4), Lukasz Japtok(4)