Barbara Wilker

Essen University Hospital — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index2.4kcitations46works3.72yr avg

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Research Topics

Sphingolipid Metabolism and Signaling(19), Cystic Fibrosis Research Advances(8), Lipid Membrane Structure and Behavior(7), Tryptophan and brain disorders(7), Circadian rhythm and melatonin(6)

Publications46 total

Phosphatidic acid is involved in regulation of autophagy in neurons in vitro and in vivo

3 cited

Pflügers Archiv - European Journal of Physiology·2024· 3 citedOpen Access

Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions

3 cited

Journal of Molecular Medicine·2024· 3 citedOpen Access

Sphingosine kills intracellular <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>

5 cited

Pathogens and Disease·2024· 5 citedOpen Access

Role of Tyrosine Nitrosylation in Stress-Induced Major Depressive Disorder: Mechanisms and Implications

2 cited

International Journal of Molecular Sciences·2023· 2 citedOpen Access

Potential involvement of the bone marrow in experimental Graves’ disease and thyroid eye disease

6 cited

Frontiers in Endocrinology·2023· 6 citedOpen Access

Linsitinib, AN IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease

Endocrine Abstracts·2023

Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease

45 cited

Frontiers in Endocrinology·2023· 45 citedOpen Access

Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo

8 cited

Journal of Molecular Medicine·2023· 8 citedOpen Access

Molecular targets of endothelial phosphatidic acid regulating major depressive disorder

6 cited

Journal of Neurochemistry·2022· 6 citedOpen Access

Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma

28 cited

Journal of Molecular Medicine·2022· 28 citedOpen Access

Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs

9 cited

PLoS ONE·2022· 9 citedOpen Access

Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice

42 cited

Journal of Biological Chemistry·2022· 42 citedOpen Access

Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs

4 cited

Scientific Reports·2021· 4 citedOpen Access

Inhaled Sphingosine Has no Adverse Side Effects in Isolated Ventilated and Perfused Pig Lungs

Research Square (Research Square)·2021Open Access

Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis

5 cited

Journal of Biological Chemistry·2021· 5 citedOpen Access

Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections

15 cited

Infection and Immunity·2020· 15 citedOpen Access

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

189 cited

Cell Reports Medicine·2020· 189 citedOpen Access

Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2

45 cited

Journal of Biological Chemistry·2020· 45 citedOpen Access

Inhibition of Acid Sphingomyelinase Blocks Infection with SARS-CoV-2

3 cited

SSRN Electronic Journal·2020· 3 citedOpen Access

Clinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side Effects

22 cited

Cellular Physiology and Biochemistry·2019· 22 citedOpen Access

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Frequent Co-authors

Erich Gulbins(40), Matthias Soddemann(27), Simone Keitsch(27), Katrin Anne Becker(17), Alexander Carpinteiro(13), Heike Grassmé(11), Carolin Sehl(11), Gregory C. Wilson(11), Michael J. Edwards(10), Johannes Kornhuber(10), Markus Kamler(10), Anne Gulbins(9), Fabian Schumacher(9), Burkhard Kleuser(9), Michael J. Edwards(8), Ildikò Szabó(7), Christian P. Müller(6), Syed A. Ahmad(6), Rabea Verhaegh(6), Charles C. Caldwell(5)