Matthias Soddemann

Essen University Hospital — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.6kcitations38works2.22yr avg
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Research Topics

Sphingolipid Metabolism and Signaling(16), Tryptophan and brain disorders(9), Circadian rhythm and melatonin(6), Cystic Fibrosis Research Advances(5), SARS-CoV-2 and COVID-19 Research(4)

Publications38 total

Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo
EMBO Molecular Medicine·2025· 2 citedOpen Access
Amitriptyline potently neutralizes distinct SARS-CoV-2 variants including D614G, Omicron BA.5, and Omicron XBB.1
Frontiers in Microbiology·2025· 1 citedOpen Access
Phosphatidic acid is involved in regulation of autophagy in neurons in vitro and in vivo
Pflügers Archiv - European Journal of Physiology·2024· 3 citedOpen Access
Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants
Viruses·2024· 3 citedOpen Access
Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants
Preprints.org·2024· 2 citedOpen Access
Sphingosine Prevents Rhinoviral Infections
International Journal of Molecular Sciences·2024· 2 citedOpen Access
Role of Tyrosine Nitrosylation in Stress-Induced Major Depressive Disorder: Mechanisms and Implications
International Journal of Molecular Sciences·2023· 2 citedOpen Access
Potential involvement of the bone marrow in experimental Graves’ disease and thyroid eye disease
Frontiers in Endocrinology·2023· 6 citedOpen Access
Reduced Sphingosine in Cystic Fibrosis Increases Susceptibility to Mycobacterium abscessus Infections
International Journal of Molecular Sciences·2023· 9 citedOpen Access
Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo
Journal of Molecular Medicine·2023· 8 citedOpen Access
Molecular targets of endothelial phosphatidic acid regulating major depressive disorder
Journal of Neurochemistry·2022· 6 citedOpen Access
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
Journal of Molecular Medicine·2022· 28 citedOpen Access
Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs
PLoS ONE·2022· 9 citedOpen Access
Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice
Journal of Biological Chemistry·2022· 42 citedOpen Access
Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs
Scientific Reports·2021· 4 citedOpen Access
Inhaled Sphingosine Has no Adverse Side Effects in Isolated Ventilated and Perfused Pig Lungs
Research Square (Research Square)·2021Open Access
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis
Journal of Biological Chemistry·2021· 5 citedOpen Access
Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections
Infection and Immunity·2020· 15 citedOpen Access
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
Cell Reports Medicine·2020· 189 citedOpen Access
Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2
Journal of Biological Chemistry·2020· 45 citedOpen Access
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Frequent Co-authors

Erich Gulbins(35), Barbara Wilker(27), Simone Keitsch(20), Katrin Anne Becker(17), Markus Kamler(12), Gregory C. Wilson(12), Johannes Kornhuber(10), Alexander Carpinteiro(10), Carolin Sehl(10), Fabian Schumacher(9), Michael J. Edwards(9), Burkhard Kleuser(9), Ildikò Szabó(8), Michael J. Edwards(8), Anne Gulbins(7), Heike Grassmé(7), Christian P. Müller(6), Rabea Verhaegh(6), Charles C. Caldwell(5), Syed A. Ahmad(5)