Cícera R. Lazzarotto

St. Jude Children's Research Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index3.2kcitations73works11.62yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

CRISPR and Genetic Engineering(44), Virus-based gene therapy research(15), CAR-T cell therapy research(13), Animal Genetics and Reproduction(12), RNA and protein synthesis mechanisms(11)

Publications73 total

Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE
Nature Biotechnology·2026· 2 citedOpen Access
A precision gene-engineered B cell medicine producing sustained levels of active factor IX for hemophilia B therapy
Molecular Therapy·2025Open Access
Custom CRISPR–Cas9 PAM variants via scalable engineering and machine learning
Nature·2025· 38 citedOpen Access
Population-scale cellular GUIDE-seq-2 and biochemical CHANGE-seq-R profiles reveal human genetic variation frequently affects Cas9 off-target activity
2025· 12 citedOpen Access
BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate
Cell stem cell·2024· 14 cited
High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease
Science Translational Medicine·2024· 15 citedOpen Access
Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34+ cell therapy to induce fetal hemoglobin for sickle cell disease
Molecular Therapy·2024· 13 citedOpen Access
Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34 <sup>+</sup> cell therapy to induce fetal hemoglobin for sickle cell disease
2024Open Access
CHANGE-seq-BE enables simultaneously sensitive and unbiased <i>in vitro</i> profiling of base editor genome-wide activity
2024· 10 citedOpen Access
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy
Nature Biomedical Engineering·2023· 39 citedOpen Access
Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells
The CRISPR Journal·2023· 6 citedOpen Access
Potent and uniform fetal hemoglobin induction via base editing
Nature Genetics·2023· 68 citedOpen Access
Process Development and Manufacturing: DEVELOPMENT OF A CLINICAL-SCALE GMP-COMPLIANT GENE-EDITED CAR T CELL MANUFACTURING PROCESS
Cytotherapy·2023
Base editing as a genetic treatment for spinal muscular atrophy
2023· 16 citedOpen Access
CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells
Frontiers in Immunology·2023· 23 citedOpen Access
Increased Potency and Uniformity of Fetal Hemoglobin Induction from Base Editing Compared to Cas9 Nuclease
Blood·2022· 1 cited
Highly Efficient &amp; Specific Repair of <i>MAGT1</i> Mutation in Xmen Patient T Cells and Hematopoietic Stem Cells
Blood·2022
Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression
Journal for ImmunoTherapy of Cancer·2022· 58 citedOpen Access
In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice
Nature Biotechnology·2022· 83 citedOpen Access
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity
Science Translational Medicine·2021· 305 citedOpen Access
page 1 of 4Next →

Frequent Co-authors

Shengdar Q. Tsai(32), Kaio César Simiano Tavares(12), Marcelo Bertolini(9), Yichao Li(8), John F. Tisdale(8), Shondra M. Pruett‐Miller(7), Mitchell J. Weiss(7), GaHyun Lee(7), Varun Katta(7), L. R. Bertolini(7), Leonardo Tondello Martins(7), Benjamin P. Kleinstiver(7), Jing Zeng(6), Scot A. Wolfe(6), Daniel E. Bauer(6), Shaina N. Porter(6), Naoya Uchida(6), Suk See De Ravin(6), L. H. Aguiar(6), Luiz Cláudio Miletti(6)