Aaron L. Nichols

California Institute of Technology — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index204citations28works1.22yr avg
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Research Topics

Nicotinic Acetylcholine Receptors Study(8), Receptor Mechanisms and Signaling(7), Neuroscience and Neuropharmacology Research(4), Advanced Fluorescence Microscopy Techniques(4), COVID-19 and Mental Health(3)

Publications28 total

BPS2026 - Computational design of protein-based biosensors toward wearable measuring of nicotine concentration and dynamics
Biophysical Journal·2026
Hydrogel Encapsulation of a Designed Fluorescent Protein Biosensor for Continuous Measurements of Sub-100 nM Nicotine
ACS Applied Bio Materials·2025
Continuous Nicotine Monitors for Personal Nicotine Pharmacokinetics: A Receptor-Aware Research Agenda
Nicotine & Tobacco Research·2025· 1 cited
Hydrogel encapsulation of a designed fluorescent protein biosensor for continuous measurements of sub-100 nanomolar nicotine
2024· 1 citedOpen Access
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids
Protein Engineering Design and Selection·2024· 4 citedOpen Access
Successful Cessation Programs that Reduce Comorbidity may Explain Surprisingly Low Smoking Rates among Hospitalized COVID-19 Patients
Qeios·2023Open Access
Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
Journal of Neuroscience·2023· 16 citedOpen Access
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids
2023· 4 citedOpen Access
Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands
eLife·2022· 3 citedOpen Access
Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
2022· 2 citedOpen Access
Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids
Journal of the American Chemical Society·2022· 10 citedOpen Access
Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-methadone for Use in Cells, Organelles, and Biofluids
2022· 3 citedOpen Access
Fluorescence Screens for Identifying Central Nervous System–Acting Drug–Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics
BIO-PROTOCOL·2022· 7 citedOpen Access
Author response: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands
2021Open Access
Encouraging Quality Improvement through the Use of a National Perfusion Database
Journal of ExtraCorporeal Technology·2021Open Access
Encouraging Quality Improvement through the Use of a National Perfusion Database.
PubMed·2021Open Access
Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands
2021· 2 citedOpen Access
Successful Cessation Programs that Reduce Comorbidity may Explain Surprisingly Low Smoking Rates among Hospitalized COVID-19 Patients
2020Open Access
Successful Cessation Programs that Reduce Comorbidity may Explain Surprisingly Low Smoking Rates among Hospitalized COVID-19 Patients
2020· 3 citedOpen Access
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum
Frontiers in Cellular Neuroscience·2019· 21 citedOpen Access
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Frequent Co-authors

Henry A. Lester(21), Dennis A. Dougherty(18), Anand K. Muthusamy(15), Bruce Cohen(12), Loren L. Looger(12), Jonathan S. Marvin(11), Amol V. Shivange(8), Charlene H. Kim(8), Zack Blumenfeld(8), Philip M. Borden(7), Hailey J. Knox(7), Stephen Grant(6), Christopher B. Marotta(6), Laura Luebbert(5), Stephen L. Mayo(5), Janice Jeon(4), Elizabeth K. Unger(4), Kallol Bera(3), Lin Tian(3), Nicholas J Friesenhahn(3)