Jae Seong Lee

Korea Advanced Institute of Science and Technology — South Korea

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index2.4kcitations102works3.12yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(55), CRISPR and Genetic Engineering(52), Virus-based gene therapy research(22), Fungal Biology and Applications(9), CAR-T cell therapy research(8)

Publications102 total

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas
Advanced Science·2026Open Access
CRISPR screen-based mammalian cell engineering for complex biotherapeutics
Trends in biotechnology·2025
Recombinase-Mediated Cassette Exchange-Based CRISPR Activation Screening Identifies Hyperosmotic Stress-Resistant Genes in Chinese Hamster Ovary Cells
ACS Synthetic Biology·2025
Comprehensive genome-scale CRISPR knockout screening of CHO cells
Scientific Data·2025· 2 citedOpen Access
Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system
Metabolic Engineering·2024· 4 citedOpen Access
Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells
Methods in molecular biology·2024· 2 cited
A precise and sustainable doxycycline-inducible cell line development platform for reliable mammalian cell engineering with gain-of-function mutations
Metabolic Engineering·2024· 3 citedOpen Access
Revisiting the impact of genomic hot spots: C12orf35 locus as a hot spot and engineering target
Biotechnology and Bioengineering·2024· 2 citedOpen Access
Context-dependent genomic locus effects on antibody production in recombinant Chinese hamster ovary cells generated through random integration
Computational and Structural Biotechnology Journal·2024· 7 citedOpen Access
Genome-Wide CRISPR/Cas9 Screening Unveils a Novel Target ATF7IP–SETDB1 Complex for Enhancing Difficult-to-Express Protein Production
ACS Synthetic Biology·2024· 11 cited
Knockout of the lysosomal membrane protein, LAMP2C, improves transient gene expression in HEK293 cells via increased intracellular plasmid availability
Biotechnology Journal·2023· 3 cited
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
Metabolic Engineering·2023· 15 cited
Limitations of the Plasmid-Based Cas9-Zinc Finger Fusion System for Homology-Directed Knock-In in Chinese Hamster Ovary Cells
Biotechnology and Bioprocess Engineering·2023· 2 cited
Implementation of ubiquitous chromatin opening elements as artificial integration sites for CRISPR/Cas9‐mediated knock‐in in mammalian cells
Engineering in Life Sciences·2023· 2 citedOpen Access
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
2022· 1 citedOpen Access
Hybrid cell line development system utilizing site-specific integration and methotrexate-mediated gene amplification in Chinese hamster ovary cells
Frontiers in Bioengineering and Biotechnology·2022· 9 citedOpen Access
Recombinase-mediated cassette exchange-based screening of a CRISPR/Cas9 library for enhanced recombinant protein production in human embryonic kidney cells: Improving resistance to hyperosmotic stress
Metabolic Engineering·2022· 13 cited
Endogenous BiP reporter system for simultaneous identification of ER stress and antibody production in Chinese hamster ovary cells
Metabolic Engineering·2022· 26 cited
Improving the secretory capacity of CHO producer cells: The effect of controlled Blimp1 expression, a master transcription factor for plasma cells
Metabolic Engineering·2021· 20 cited
An optimized genome-wide, virus-free CRISPR screen for mammalian cells
Cell Reports Methods·2021· 10 citedOpen Access
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Frequent Co-authors

Gyun Min Lee(25), Helene Faustrup Kildegaard(16), Nathan E. Lewis(10), Lasse Ebdrup Pedersen(9), Lise Marie Grav(9), Karen Julie la Cour Karottki(6), Hooman Hefzi(5), Nuhu Alam(5), Tae Soo Lee(5), Seunghyeon Shin(5), Su Hyun Kim(5), Shangzhong Li(4), Ki Nam Yoon(4), Tae Kwang Ha(4), Kai Xiong(4), Philipp N. Spahn(3), Hae Jin Cho(3), Sung Wook Shin(3), Jin Hyoung Park(3), Mi Ja Shim(3)