Lasse Ebdrup Pedersen

Novo Nordisk Foundation — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index2.7kcitations61works18.72yr avg
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Research Topics

CRISPR and Genetic Engineering(34), Viral Infectious Diseases and Gene Expression in Insects(25), RNA and protein synthesis mechanisms(13), Microbial Metabolic Engineering and Bioproduction(10), Monoclonal and Polyclonal Antibodies Research(7)

Publications61 total

Unraveling productivity-enhancing genes in Chinese hamster ovary cells via CRISPR activation screening using recombinase-mediated cassette exchange system
Metabolic Engineering·2024· 4 citedOpen Access
Deep mining of antibody phage-display selections using Oxford Nanopore Technologies and Dual Unique Molecular Identifiers
New Biotechnology·2024· 6 citedOpen Access
Design and engineering of bispecific antibodies: insights and practical considerations
Frontiers in Bioengineering and Biotechnology·2024· 46 citedOpen Access
Structural trends in antibody-antigen binding interfaces: a computational analysis of 1833 experimentally determined 3D structures
Computational and Structural Biotechnology Journal·2023· 30 citedOpen Access
A window into the human immune system: comprehensive characterization of the complexity of antibody complementary-determining regions in functional antibodies
mAbs·2023· 26 citedOpen Access
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
Metabolic Engineering·2023· 15 cited
Eliminating OFF-frame clones in randomized gene libraries: An improved split β-lactamase enrichment system
New Biotechnology·2023Open Access
Expanding the CRISPR toolbox for Chinese hamster ovary cells with comprehensive tools for Mad7 genome editing
Biotechnology and Bioengineering·2023· 12 citedOpen Access
Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals
Metabolic Engineering·2023· 54 citedOpen Access
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
2022· 1 citedOpen Access
Immobilization-Free Binding and Affinity Characterization of Higher Order Bispecific Antibody Complexes Using Size-Based Microfluidics
Analytical Chemistry·2022· 12 citedOpen Access
Rational and evolutionary engineering of Saccharomyces cerevisiae for production of dicarboxylic acids from lignocellulosic biomass and exploring genetic mechanisms of the yeast tolerance to the biomass hydrolysate
Biotechnology for Biofuels and Bioproducts·2022· 19 citedOpen Access
Additional file 3 of Rational and evolutionary engineering of Saccharomyces cerevisiae for production of dicarboxylic acids from lignocellulosic biomass and exploring genetic mechanisms of the yeast tolerance to the biomass hydrolysate
Figshare·2022Open Access
An optimized genome-wide, virus-free CRISPR screen for mammalian cells
Cell Reports Methods·2021· 10 citedOpen Access
Mad7: An IP Friendly CRISPR Enzyme
Research Square (Research Square)·2021· 1 citedOpen Access
A dual-reporter system for investigating and optimizing protein translation and folding in E. coli
Nature Communications·2021· 41 citedOpen Access
Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli
Communications Biology·2021· 22 citedOpen Access
Mad7: An IP friendly CRISPR enzyme
2021· 4 citedOpen Access
An optimized genome-wide, virus-free CRISPR screen for mammalian cells
Cell Reports Methods·2021· 36 citedOpen Access
Data and analysis scripts for "Mad7: An IP friendly alternative to Cas9"
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
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Frequent Co-authors

Helene Faustrup Kildegaard(19), Gyun Min Lee(15), Jae Seong Lee(14), Nathan E. Lewis(14), Hooman Hefzi(11), Alex Toftgaard Nielsen(10), Lise Marie Grav(10), Karen Julie la Cour Karottki(9), Songyuan Li(7), Shangzhong Li(6), Philipp N. Spahn(6), Steffen Goletz(6), Markus J. Herrgård(5), Daniel Ley(5), Mikael Rørdam Andersen(5), Anna Koza(5), Andreas V. Madsen(5), Peter Kristensen(5), Kai Xiong(5), Tadas Jakočiūnas(4)