Daniel Ley

Novo Nordisk Foundation — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index705citations14works8.52yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(13), CRISPR and Genetic Engineering(8), Microbial Metabolic Engineering and Bioproduction(7), Protein purification and stability(3), RNA and protein synthesis mechanisms(1)

Publications14 total

Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells
Nature Metabolism·2025· 15 citedOpen Access
Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells
2024· 2 citedOpen Access
Multiplex secretome engineering enhances recombinant protein production and purity
Nature Communications·2020· 119 citedOpen Access
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Nature Communications·2020· 130 citedOpen Access
Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion
Metabolic Engineering·2019· 32 citedOpen Access
BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effects
Journal of Biotechnology·2019· 9 cited
Multiplex secretome engineering enhances recombinant protein production and purity
2019· 16 citedOpen Access
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
2018· 20 citedOpen Access
Fed-Batch CHO Cell Culture for Lab-Scale Antibody Production
Methods in molecular biology·2017· 20 cited
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Scientific Reports·2017· 60 citedOpen Access
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism
Cell Systems·2016· 263 citedOpen Access
Multi‐omic profiling of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production
Biotechnology and Bioengineering·2015· 19 citedOpen Access
Multi-omic profiling of EPO producing CHO cell panel reveals metabolic adaptation to heterologous protein production
Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)·2015Open Access
Engineering amino acid supply pathways in Chinese hamster ovary cells
2014

Frequent Co-authors

Helene Faustrup Kildegaard(13), Mikael Rørdam Andersen(8), Nathan E. Lewis(8), Gyun Min Lee(7), Hooman Hefzi(6), Johnny Arnsdorf(6), Björn G. Voldborg(6), Lasse Ebdrup Pedersen(5), Jahir M. Gutierrez(5), Tune Wulff(4), Shangzhong Li(4), Bernhard Ø. Palsson(4), Stefan Kol(4), Marianne Decker(4), Michael J. Betenbaugh(3), Lars K. Nielsen(3), Thomas Beuchert Kallehauge(3), Lise Marie Grav(3), Sanne Schoffelen(3), Anders Holmgaard Hansen(3)