Jérémie Le Pen

Rockefeller University — United States

Medicine · Health Sciences

18h-index7.8kcitations32works10.82yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(10), Genetics, Aging, and Longevity in Model Organisms(9), CRISPR and Genetic Engineering(9), interferon and immune responses(7), RNA regulation and disease(7)

Publications32 total

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains
The Journal of Experimental Medicine·2025· 7 citedOpen Access
A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity
The Journal of Experimental Medicine·2024· 10 citedOpen Access
A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist
PLoS Biology·2024· 12 citedOpen Access
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency
The Journal of Experimental Medicine·2024· 17 citedOpen Access
The antiviral state of the cell: lessons from SARS-CoV-2
Current Opinion in Immunology·2024· 18 citedOpen Access
A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist
2024· 1 citedOpen Access
Inherited deficiency of the OAS-RNase L pathway in children with MIS-C
Clinical Immunology·2023
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
Science·2022· 156 citedOpen Access
ER-associated RNA silencing promotes ER quality control
Nature Cell Biology·2022· 37 citedOpen Access
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
The Journal of Experimental Medicine·2022· 114 citedOpen Access
Replication and single-cycle delivery of SARS-CoV-2 replicons
Science·2021· 81 citedOpen Access
Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice
2021· 4 citedOpen Access
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
Cell Host & Microbe·2020· 168 citedOpen Access
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
Cell·2020· 429 citedOpen Access
Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice
2020· 2 citedOpen Access
piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans
UNC Libraries·2020Open Access
Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks
2020· 52 citedOpen Access
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science·2020· 2.8k citedOpen Access
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Science·2020· 2.4k citedOpen Access
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
2020· 36 citedOpen Access
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Frequent Co-authors

Charles M. Rice(16), Eleftherios Michailidis(12), Eric A. Miska(11), Hans-Heinrich Hoffmann(9), Jean‐Laurent Casanova(9), William M. Schneider(9), Joseph M. Luna(9), Inna Ricardo-Lax(9), Qian Zhang(8), Alison W. Ashbrook(8), Margaret R. MacDonald(8), Shen‐Ying Zhang(7), Francisco J. Sánchez‐Rivera(7), Avery Peace(7), Ansgar F. Stenzel(7), John T. Poirier(7), Danyel Lee(7), Lucy Bizien(6), Emmanuelle Jouanguy(6), Aurélie Cobat(6)