Shirley Yeh

PTC Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index1.6kcitations19works0.02yr avg
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Research Topics

Biochemical and Molecular Research(9), RNA modifications and cancer(5), RNA Research and Splicing(4), Cancer, Hypoxia, and Metabolism(4), Neonatal Health and Biochemistry(4)

Publications19 total

Comparison of pharmaceutical properties and biological activities of prednisolone, deflazacort, and vamorolone in DMD disease models
Human Molecular Genetics·2023· 16 citedOpen Access
Evaluation of the Biodistribution, Efficacy, and Side-Effect Profile of Deflazacort, Prednisolone and Vamorolone in a DMD Mouse Model (S34.010)
Neurology·2023
Supplementary Excel file-1 from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Excel file-1 from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Data from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Data from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Figures S1-S7; Supplementary Tables S1-S7; and Supplementary Materials and Methods from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Figures S1-S7; Supplementary Tables S1-S7; and Supplementary Materials and Methods from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Frontiers in Oncology·2022· 13 citedOpen Access
Small molecule splicing modifiers with systemic HTT-lowering activity
Nature Communications·2021· 83 citedOpen Access
In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor
Xenobiotica·2021· 7 cited
I01 Orally bioavailable small molecule splicing modifiers with systemic and even htt-lowering activity in vitro and in vivo
2021
Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Molecular Cancer Therapeutics·2018· 77 cited
Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule<i>SMN2</i>splicing modifier in mouse models of spinal muscular atrophy
Human Molecular Genetics·2016· 35 citedOpen Access
146. Suppression of a Nonsense mutation in a mouse model of Hurler syndrome
Molecular Genetics and Metabolism·2009
12. Suppression of a nonsense mutation in a mouse model of Hurler syndrome
Molecular Genetics and Metabolism·2009
PTC124 targets genetic disorders caused by nonsense mutations
Nature·2007· 1.1k cited
Development, validation and application of assays to quantify metrifonate and 2,2-dichlorovinyl dimethylphosphate in human body fluids
Journal of Chromatography B Biomedical Sciences and Applications·2000· 13 cited
THE INTERACTION BETWEEN <i>TOXOPLASMA GONDII</i> AND MAMMALIAN CELLS
The Journal of Experimental Medicine·1972· 228 citedOpen Access

Frequent Co-authors

Marla Weetall(15), Christopher R. Trotta(11), Young‐Choon Moon(11), Nicole Risher(11), Joseph M. Colacino(11), Stuart W. Peltz(10), John Babiak(9), Jason D. Graci(9), Wencheng Li(9), Josephine Sheedy(9), Ronald Kong(9), Seongwoo Hwang(8), Neil G. Almstead(8), Jean Hedrick(8), Allan Jacobson(8), Liangxian Cao(8), Jiyuan Ma(8), Bansri Furia(8), Janet Petruska(8), Ellen Welch(7)