David Stokoe

Biochemistry, Genetics and Molecular Biology · Life Sciences

63h-index24.4kcitations271works1.12yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(65), Cancer, Hypoxia, and Metabolism(47), Ubiquitin and proteasome pathways(37), Protein Kinase Regulation and GTPase Signaling(25), Mitochondrial Function and Pathology(24)

Publications271 total

Figure S7 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Table S4 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Figure S5 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Figure S1 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Key Resources Table from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Table S2 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Figure S6 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Data from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Table S1 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Table S3 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Figure S4 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Figure S3 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Figure S2 from Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i>-Mutant Lung Cancer
2025Open Access
Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i> -Mutant Lung Cancer
Cancer Research·2025Open Access
BiDAC-dependent degradation of plasma membrane proteins by the endolysosomal system
Nature Communications·2025· 3 citedOpen Access
Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint
Immunity·2024· 14 citedOpen Access
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
Communications Chemistry·2024· 7 citedOpen Access
Abstract B017: Loss of UXS1 selectively kills KEAP1 mutant cancer cell lines by depleting pyrimidines and inducing replication stress
Molecular Cancer Therapeutics·2024
Morphological and genetic screens reveal mechanisms of BiDAC-induced plasma membrane protein degradation
2024Open Access
Structure of the p53 degradation complex from HPV16
Nature Communications·2024· 44 citedOpen Access
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Frequent Co-authors

Frank McCormick(8), Somasekar Seshagiri(7), Daphne A. Haas‐Kogan(6), Peter M. Haverty(6), Daphne A. Haas-Kogan(6), Zachary A. Knight(5), Kevan M. Shokat(5), Howard M. Stern(5), Mitchel S. Berger(5), William A. Weiss(4), Zora Modrušan(4), Zemin Zhang(4), Frédéric J. de Sauvage(4), Thomas D. Wu(4), Kathleen R. Lamborn(4), Michael D. Prados(3), Tarık Tihan(3), Len Stephens(3), Phillip T. Hawkins(3), Jeremy Stinson(3)