Juraj Zajac

Czech Academy of Sciences, Institute of Biophysics — Czech Republic

Medicine · Health Sciences

11h-index499citations19works0.02yr avg
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Research Topics

Metal complexes synthesis and properties(8), RNA Interference and Gene Delivery(5), Click Chemistry and Applications(5), Nanoparticle-Based Drug Delivery(4), Crystallization and Solubility Studies(4)

Publications19 total

A Multi‐action Pt<sup>IV</sup> Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells
Angewandte Chemie·2020· 8 cited
A Multi‐action Pt<sup>IV</sup> Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells
Angewandte Chemie International Edition·2020· 43 cited
Platinum (IV) Derivatives with Cinnamate Axial Ligands as Potent Agents Against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells
Angewandte Chemie International Edition·2019· 43 cited
Platinum (IV) Derivatives with Cinnamate Axial Ligands as Potent Agents Against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells
Angewandte Chemie·2019· 5 cited
A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton
Journal of Medicinal Chemistry·2019· 58 cited
Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices<i>via</i>post-assembly modification
Chemical Science·2019· 31 citedOpen Access
Correction: Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells
Oncotarget·2018· 3 citedOpen Access
Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells
Oncotarget·2018· 26 citedOpen Access
New Acridine Thiourea Gold(I) Anticancer Agents: Targeting the Nucleus and Inhibiting Vasculogenic Mimicry
ACS Chemical Biology·2017· 61 cited
Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects
Inorganic Chemistry·2017· 48 citedOpen Access
CCDC 1577688: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1507593: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose‐Coated Magnetic Nanoparticles
Chemistry - A European Journal·2016· 15 cited
CCDC 1483570: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Highly potent extranuclear-targeted luminescent iridium(<scp>iii</scp>) antitumor agents containing benzimidazole-based ligands with a handle for functionalization
Chemical Communications·2016· 62 cited
CCDC 1483571: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin
Journal of Inorganic Biochemistry·2015· 60 cited
Influence of the binding of reduced NAMI-A to human serum albumin on the pharmacokinetics and biological activity
Dalton Transactions·2014· 36 cited
[Malignant neoplasm of the lymphatic system].
PubMed·1971

Frequent Co-authors

Viktor Brabec(18), Vojtěch Novohradský(13), Jana Kašpárková(11), Hana Kostrhunová(7), Sergio A. Pérez(5), Antonio Donaire(5), Lenka Marková(5), José Ruiz(4), Oldřich Vrána(4), Jyoti Yellol(3), Gorakh S. Yellol(3), Gloria Vigueras(3), Christoph Janiak(3), C. De Haro(2), Consuelo Vicente(2), Ana Zamora(2), Delia Bautista(2), Dan Gibson(2), Francesco P. Intini(2), Teresa Saltarella(2)