Jason M. Tonne

WinnMed — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.5kcitations50works5.62yr avg
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Research Topics

Virus-based gene therapy research(21), CAR-T cell therapy research(16), Immunotherapy and Immune Responses(10), Pancreatic function and diabetes(9), Viral Infectious Diseases and Gene Expression in Insects(9)

Publications50 total

Engagement of the T cell receptor against an oncolytic virus generates a population of hypereffector CAR T cells with potent antitumor activity
2025Open Access
Abstract B063: Succinate based metabolic reprogramming of CAR-macrophages for ovarian cancer immunotherapy
Cancer Research·2025
T cell exhaustion in poorly immunogenic HCC is partially rescued by checkpoint blockade but suppressed by oncolytic virotherapy
Molecular Therapy·2025· 1 citedOpen Access
Exploiting viral infection/vaccination to focus high-affinity T cell populations into tumors using oncolytic viro-immunotherapy
Molecular Therapy·2025· 3 citedOpen Access
Immunodominant antiviral T cell responses outcompete immuno-subdominant antitumor responses to reduce the efficacy of oncolytic viroimmunotherapy
2025· 1 citedOpen Access
Cancer Immunotherapy Using AIRE Conditioning of the Tumor Epitopeome
2024· 1 citedOpen Access
Intranasal Prime–Boost with Spike Vectors Generates Antibody and T-Cell Responses at the Site of SARS-CoV-2 Infection
Vaccines·2024· 4 citedOpen Access
APOBEC3B expression in 293T viral producer cells drives mutations in chimeric antigen receptors and reduces CAR T cell efficacy
Molecular Therapy Oncology·2024· 3 citedOpen Access
Smoldering oncolysis by foamy virus carrying CD19 as a CAR target escapes CAR T detection by genomic modification
Molecular Therapy Oncology·2024· 3 citedOpen Access
Expression of tumor antigens within an oncolytic virus enhances the anti-tumor T cell response
Nature Communications·2024· 46 citedOpen Access
Activation of APOBEC3B in Self-Inactivating Lentiviral-Based CAR T Cell Production Increases the Mutational Load and Decreases the Killing Efficiency of CAR T Cells
The Journal of Immunology·2024
Chimerization of the Anti-Viral CD8+ T Cell Response with A Broad Anti-Tumor T Cell Response Reverses Inhibition of Checkpoint Blockade Therapy by Oncolytic Virotherapy
2023· 3 citedOpen Access
A phase I oncolytic virus trial with vesicular stomatitis virus expressing human interferon beta and tyrosinase related protein 1 administered intratumorally and intravenously in uveal melanoma: safety, efficacy, and T cell responses
Frontiers in Immunology·2023· 28 citedOpen Access
Efficacy of function-enhanced, re-activatable, dual-specific CAR T cells pre-loaded with oncolytic virus for immunotherapy of high-grade glioma.
Journal of Clinical Oncology·2023· 1 cited
Trap and ambush therapy using sequential primary and tumor escape-selective oncolytic viruses
Molecular Therapy — Oncolytics·2023· 6 citedOpen Access
Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice
Science Translational Medicine·2022· 180 citedOpen Access
Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy
Nature Communications·2021· 25 citedOpen Access
Vesicular Stomatitis Virus Encoding a Destabilized Tumor Antigen Improves Activation of Anti-tumor T Cell Responses
Molecular Therapy·2020· 7 citedOpen Access
Oncolytic virus-derived type I interferon restricts CAR T cell therapy
Nature Communications·2020· 111 citedOpen Access
Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors
Neuro-Oncology·2020· 15 citedOpen Access
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Frequent Co-authors

Yasuhiro Ikeda(24), Richard G. Vile(21), Jill Thompson(17), Laura Evgin(11), Toshie Sakuma(11), Rosa María Díaz(9), Benjamin Kendall(9), Yogish C. Kudva(8), Alessandro Cataliotti(8), Muriel Metko(8), Amanda L. Huff(7), Christopher B. Driscoll(7), José S. Pulido(7), Alan Melcher(7), Seiga Ohmine(7), Thanich Sangsuwannukul(7), Madelyn Moore(6), Matthew Schuelke(6), Tayaramma Thatava(6), Mason Webb(6)