Wayne N. Frankel

Columbia University Irving Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

47h-index10.6kcitations113works3.52yr avg
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Research Topics

Genetics and Neurodevelopmental Disorders(17), Animal Genetics and Reproduction(17), Neuroscience and Neuropharmacology Research(16), CRISPR and Genetic Engineering(13), RNA Research and Splicing(12)

Publications113 total

Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy
Brain·2025· 4 cited
Impaired axon initial segment structure and function in a model of <i>ARHGEF9</i> developmental and epileptic encephalopathy
Proceedings of the National Academy of Sciences·2024· 3 citedOpen Access
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy
Neurobiology of Disease·2016· 30 citedOpen Access
DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease
PLoS ONE·2015· 34 citedOpen Access
GABAergic Circuits in the Thalamus MeCP2 Is Required for Normal Development of
2015
A genetic interaction network model of a complex neurological disease
Genes Brain & Behavior·2014· 13 citedOpen Access
Unraveling Genetic Modifiers in the Gria4 Mouse Model of Absence Epilepsy
PLoS Genetics·2014· 24 citedOpen Access
Loss of MeCP2 From Forebrain Excitatory Neurons Leads to Cortical Hyperexcitation and Seizures
Journal of Neuroscience·2014· 128 citedOpen Access
Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells
Journal of Neuroscience·2014· 68 citedOpen Access
Elevated <i>Id2</i> Expression Results in Precocious Neural Stem Cell Depletion and Abnormal Brain Development
Stem Cells·2013· 24 citedOpen Access
CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs, Including Genes Associated with Regulation of Synaptic Function
PLoS Genetics·2012· 130 citedOpen Access
Aberrant sodium channel activity in the complex seizure disorder of <i>Celf4</i> mutant mice
The Journal of Physiology·2012· 36 citedOpen Access
The genomic landscape shaped by selection on transposable elements across 18 mouse strains
Genome biology·2012· 193 citedOpen Access
A new mode of corticothalamic transmission revealed in the Gria4−/− model of absence epilepsy
Nature Neuroscience·2011· 179 citedOpen Access
Etiology of a genetically complex seizure disorder in Celf4 mutant mice
Genes Brain & Behavior·2011· 44 citedOpen Access
A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice
Human Molecular Genetics·2010· 66 citedOpen Access
Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus
Neurobiology of Disease·2010· 89 citedOpen Access
A Missense Mutation in a Highly Conserved Alternate Exon of Dynamin-1 Causes Epilepsy in Fitful Mice
PLoS Genetics·2010· 107 citedOpen Access
Genetics of complex neurological disease: challenges and opportunities for modeling epilepsy in mice and rats
Trends in Genetics·2009· 80 citedOpen Access
<i>Szt2</i>, a novel gene for seizure threshold in mice
Genes Brain & Behavior·2009· 56 citedOpen Access
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Frequent Co-authors

Connie L. Mahaffey(8), John M. Coffin(7), Verity A. Letts(6), Gregory A. Cox(5), Joseph H. Nadeau(4), Cathleen Lutz(4), Janan T. Eppig(3), Jonathan P. Stoye(3), Benjamin A. Taylor(3), Kevin L. Seburn(3), Dan Goldowitz(3), Joseph S. Takahashi(3), F S Bartlett(2), E H Birkenmeier(2), Alicia Valenzuela(2), Bruce A. Hamilton(2), Anne W. Kerrebrock(2), Kenro Kusumi(2), Bruce W. Birren(2), Eric S. Lander(2)