John W. Adams

University of California, San Diego — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.7kcitations29works3.52yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(9), Receptor Mechanisms and Signaling(7), Sphingolipid Metabolism and Signaling(7), Cell death mechanisms and regulation(3), PI3K/AKT/mTOR signaling in cancer(3)

Publications29 total

Unique pharmacological properties of etrasimod among <scp>S1P</scp> receptor modulators
FEBS Open Bio·2024· 7 citedOpen Access
LMIC-24. ASSESSING THE TREATMENT OUTCOMES OF PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA UNDER A U.S.-MEXICO CROSS-BORDER NEURO-ONCOLOGY PROGRAM
Neuro-Oncology·2024Open Access
Abstract 14871: APD588, a Novel, Selective S1P Receptor Modulator, Regulates Inflammatory Responses and Attenuates Cardiac Dysfunction Following Experimental Myocardial Infarction in Mice
Circulation·2020· 1 cited
Etrasimod, a Selective S1P <sub>1,4,5</sub> Receptor Modulator, Exhibits Differential G Protein Signaling Compared to Other S1P Receptor Modulators
The FASEB Journal·2020· 1 cited
Intravenous Infusion of the β(3)-Adrenergic Receptor Antagonist APD418 Improves Left Ventricular Systolic Function in Dogs with Systolic Heart Failure: β(3)-Adrenergic Receptor Antagonist in Heart Failure
Journal of Cardiac Failure·2020
APD588, a novel, selective S1P- receptor modulator, inhibits inflammation and airway hyperresponsiveness in the ovalbumin-induced model of allergic asthma
The Journal of Immunology·2019
The Selective Sphingosine 1-Phosphate Receptor Modulator Etrasimod Regulates Lymphocyte Trafficking and Alleviates Experimental Colitis
Journal of Pharmacology and Experimental Therapeutics·2019· 48 citedOpen Access
Angiotensin (1–7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor
Cellular Signalling·2018· 56 cited
Etrasimod, a Novel Sphingosine‐1‐Phosphate Receptor (S1PR1) Modulator, Lacks Functional Activity at S1P2 Receptors
The FASEB Journal·2017
Functional Activity of Etrasimod and a Diverse Panel of Sphingosine‐1‐Phosphate Receptor (S1PR1) Modulators at S1P4 Receptors
The FASEB Journal·2017
Discovery of 2-(((1<i>r</i>,4<i>r</i>)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Journal of Medicinal Chemistry·2017· 17 citedOpen Access
Quantitative measurement of HER2 expression in breast cancers: comparison with ‘real-world’ routine HER2 testing in a multicenter Collaborative Biomarker Study and correlation with overall survival
Breast Cancer Research·2015· 45 citedOpen Access
Obatoclax Mesylate, a Pan–Bcl-2 Inhibitor, in Combination with Docetaxel in a Phase 1/2 Trial in Relapsed Non–Small-Cell Lung Cancer
Journal of Thoracic Oncology·2013· 36 citedOpen Access
Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor
American Journal of Physiology-Heart and Circulatory Physiology·2008· 52 cited
Gαq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Gαq mediated hypertrophy
Journal of Molecular and Cellular Cardiology·2006· 39 cited
Ca2+ Dysregulation Induces Mitochondrial Depolarization and Apoptosis
Journal of Biological Chemistry·2005· 64 citedOpen Access
Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho
Journal of Molecular and Cellular Cardiology·2004· 71 cited
Akt-mediated Cardiomyocyte Survival Pathways Are Compromised by Gαq-induced Phosphoinositide 4,5-Bisphosphate Depletion
Journal of Biological Chemistry·2003· 68 citedOpen Access
G-proteins in growth and apoptosis: lessons from the heart
Oncogene·2001· 121 citedOpen Access
Cardiomyocyte Apoptosis Induced by Gαq Signaling Is Mediated by Permeability Transition Pore Formation and Activation of the Mitochondrial Death Pathway
Circulation Research·2000· 105 cited
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Frequent Co-authors

Joan Heller Brown(9), Ibragim Gaidarov(7), David J. Unett(6), H. Kiyomi Komori(4), Gerald W. Dorn(3), Scott A. Henderson(3), Amy L. Howes(3), Shigeki Miyamoto(3), Xiaohua Chen(3), Joel Gatlin(3), Xiaohua Chen(3), Valerie P. Sah(2), Christopher K. Means(2), Elizabeth A. Woodcock(2), Todd L. Anthony(2), Graeme Semple(2), Dominic P. Behan(2), Hussien Al‐Shamma(2), Martin F. Graham(2), Amy Willey(2)