Gustavo F. Contreras

University of Chicago — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index677citations40works1.02yr avg
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Research Topics

Ion channel regulation and function(19), Cardiac electrophysiology and arrhythmias(11), Neuroscience and Neural Engineering(7), Neuroscience and Neuropharmacology Research(5), Electrochemical Analysis and Applications(5)

Publications40 total

Closed state structure of the pore revealed by uncoupled Shaker K+ channel
Nature Communications·2025Open Access
Structural basis of voltage-dependent gating in BK channels
Nature Communications·2025· 6 citedOpen Access
Closed State Structure of the Pore Revealed by Uncoupled Shaker K+ Channel
2025Open Access
The BK channel-NS1619 agonist complex reveals molecular insights on allosteric activation gating
2025· 3 citedOpen Access
Closed State Structure of the Pore Revealed by Uncoupled Shaker K <sup>+</sup> Channel
2025Open Access
BPS2025 - A key residue in S4-S5 linker controls electromechanical coupling in Kv channels
Biophysical Journal·2025
Ca2+ bound aplysia Slo1 - R196Q
2024
NS1619 activates the BK channel by stabilizing S6 helix and strengthens electromechanical coupling
Biophysical Journal·2024Open Access
BK channel voltage-gating mechanism probed by single-particle cryo-EM
Biophysical Journal·2024Open Access
Structural Basis of Voltage-Dependent Gating in BK Channels and Its Coupling to the Calcium Sensor
2023· 11 citedOpen Access
Prestin's structural cycle and the molecular basis of electromotility in outer hair cells
Biophysical Journal·2022
An optimized protocol for on-column nanodisc formation
Biophysical Journal·2022· 5 cited
Direct inhibition of CaV2.3 by Gem is dynamin dependent and does not require a direct alfa/beta interaction
Biochemical and Biophysical Research Communications·2021
The conformational cycle of prestin underlies outer-hair cell electromotility
Nature·2021· 101 cited
Cryo-EM Structure of dolphin Prestin: Inhibited II (Sulfate +Salicylate) state
2021· 1 cited
Cryo-EM Structure of dolphin Prestin: Inhibited I (Chloride + Salicylate)
2021
Cryo-EM Structure of dolphin Prestin: Sensor Down I (Expanded) state
2021
Cryo-EM Structures of Prestin and the Molecular Basis of Outer Hair Cell Electromotility
2021· 7 citedOpen Access
Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1
Nature·2020· 80 citedOpen Access
A Molecular Mechanism for Gating Polarity in Non-Domain-Swapped Kv Channels
Biophysical Journal·2020Open Access
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Frequent Co-authors

Eduardo Perozo(19), Ramón Latorre(15), Carlos González(13), Alan Neely(10), Rong Shen(10), Michael David Clark(9), Navid Bavi(7), Bharat Reddy(6), Wieslawa Milewski(6), Osvaldo Álvarez(5), Karen Castillo(4), Amaury Pupo(4), Francisco Bezanilla(4), Willy Carrasquel-Ursulaez(3), Fernando D. González‐Nilo(3), Yichen Liu(3), Romina V. Sepúlveda(2), Daniel Aguayo(2), Francisco J. Morera(2), Óscar Arteaga(2)