Malcolm L. Gefter

Biochemistry, Genetics and Molecular Biology · Life Sciences

46h-index7.6kcitations87works0.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(24), Monoclonal and Polyclonal Antibodies Research(23), T-cell and B-cell Immunology(16), Bacterial Genetics and Biotechnology(15), DNA Repair Mechanisms(13)

Publications87 total

Topologically Engineered, Superdimeric α-CD19 x α-CD20 Bispecific Antibodies with Dual Enhanced Fc Domains: New Class of Natural Killer (NK)/Monocyte Engagers for Deep B Cell Depletion in Lupus Nephritis
Journal of the American Society of Nephrology·2025
Abstract 2730: Beyond antibodies and CAR-T: Topologically-engineered, super-dimeric antibody-like molecules with dual Fc domains for trispecific, bivalent targeting of CD19, CD20, and Fcgamma receptors
Cancer Research·2024
Topologically engineered antibodies and Fc-fusion proteins: a new class of multifunctional therapeutic candidates for SARS-CoV-2, cancer, and other disease
2022· 1 citedOpen Access
Isolation of hybridomas expressing region gene segment by using a sci mRNA sequences in whole cell lysa (monoclonal antibodies/filter hybridization/bacterial lipopolysacchar
2016
Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries
Nature Chemical Biology·2009· 7 citedOpen Access
Design, synthesis and selection of DNA-encoded small-molecule libraries
Nature Chemical Biology·2009· 675 citedOpen Access
Efficacy of a therapeutic cocaine vaccine in rodent models
Nature Medicine·1996· 222 cited
Peptide Therapy for Treatment of Allergic Diseases
Clinical Immunology and Immunopathology·1996· 20 cited
Peripheral tolerance in T cell receptor‐transgenic mice: Evidence for T cell anergy
European Journal of Immunology·1996· 53 cited
Silencing of immunodominant epitopes by contiguous sequences in complex synthetic peptides
Cellular Immunology·1992· 20 cited
Comparison of class I‐ and II‐restricted T cell recognition of the identical peptide
European Journal of Immunology·1991· 5 cited
Genetic recombination in the α<sub>2</sub> domain of the E<sub>α</sub> chain yields an E<sup>d</sup> molecule with altered T cell activation
European Journal of Immunology·1990· 3 cited
Immunological activity of covalently linked T-cell epitopes
Nature·1990· 90 cited
The molecular basis of a VH gene polymorphism that determines the expression of a major idiotype
Molecular Immunology·1989· 1 cited
GENE CONVERSION AND THE GENERATION OF ANTIBODY DIVERSITY
Annual Review of Biochemistry·1989· 90 cited
Murine MHC Polymorphism and T Cell Specificities
Science·1989· 78 cited
Preliminary crystallographic studies of the Fab fragment of an anti-azophenylarsonate antibody
Journal of Molecular Biology·1989· 1 cited
Evolution of Antibody Variable Region Structure during the Immune Response
Immunological Reviews·1987· 149 cited
Interaction of peptide antigens and class II major histocompatibility complex antigens
Nature·1986· 215 cited
Immunology: Development and modification of the lymphocyte repertoire
Nature·1986· 10 cited
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Frequent Co-authors

Thomas B. Kornberg(6), Ann Marshak‐Rothstein(5), Tim Manser(5), Ian J. Molineux(5), Thomas J. Briner(4), John A. Smith(4), Lawrence J. Wysocki(4), Michael N. Margolies(4), James L. Manley(3), Miriam Siekevitz(3), Thomas Gridley(2), Yukinori Hirota(2), Marvin Gold(2), Jerard Hurwitz(2), Mark T. Scherer(2), Richard I. Near(2), Thomas L. Rothstein(2), Roberta C. Reuben(2), Phillip A. Sharp(2), Matthew Clark(1)