Zhi-Yong Yang

OPKO Health (United States) — United States

Immunology and Microbiology · Life Sciences

50h-index14.1kcitations67works1.52yr avg
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Research Topics

HIV Research and Treatment(35), Immune Cell Function and Interaction(20), Virus-based gene therapy research(11), Monoclonal and Polyclonal Antibodies Research(11), Viral Infections and Outbreaks Research(10)

Publications67 total

A phase 1/2a, multicenter, first-in-human, open-label clinical trial evaluating MDX2001, a tetraspecific T cell engager-expander in patients with advanced solid tumors.
Journal of Clinical Oncology·2025· 1 cited
A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo
Science Translational Medicine·2024· 2 cited
Activation and lysis of human CD4 cells latently infected with HIV-1
Nature Communications·2015· 99 citedOpen Access
Evaluation of candidate vaccine approaches for MERS-CoV
Nature Communications·2015· 311 citedOpen Access
Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection
Journal of Virology·2015· 121 citedOpen Access
Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection
Journal of Virology·2015· 104 citedOpen Access
Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
Nature·2014· 390 citedOpen Access
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
Science Translational Medicine·2014· 239 citedOpen Access
Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination
Science Translational Medicine·2014· 439 citedOpen Access
Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection
PLoS ONE·2014· 267 citedOpen Access
Antibodies VRC01 and 10E8 Neutralize HIV-1 with High Breadth and Potency Even with Ig-Framework Regions Substantially Reverted to Germline
The Journal of Immunology·2014· 93 citedOpen Access
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
Nature·2013· 146 citedOpen Access
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2
Immunity·2013· 383 citedOpen Access
Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04
Journal of Virology·2012· 36 citedOpen Access
Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens
Virology·2012· 45 cited
Immunogenicity and clinical protection against equine influenza by DNA vaccination of ponies
Vaccine·2012· 40 citedOpen Access
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
Nature·2011· 839 citedOpen Access
Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination
Science·2010· 340 cited
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Science·2010· 1.8k cited
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
Science·2010· 1.2k cited
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Frequent Co-authors

Gary J. Nabel(48), John R. Mascola(24), Wing-Pui Kong(23), Ling Xu(21), Peter D. Kwong(12), Srinivas S. Rao(11), Norman L. Letvin(11), David C. Montefiori(9), Bimal K. Chakrabarti(9), Stephen D. Schmidt(7), Elizabeth G. Nabel(7), Tongqing Zhou(6), Ivelin S. Georgiev(6), Wei Shi(6), John-Paul Todd(6), Sijy O’Dell(5), Mark K. Louder(5), Barton F. Haynes(5), Sung‐Youl Ko(5), Xuejun Chen(5)