Richard Hargreaves

Bristol-Myers Squibb (Germany) — Germany

Medicine · Health Sciences

16h-index1.3kcitations41works5.02yr avg
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Research Topics

Migraine and Headache Studies(5), Medical Imaging Techniques and Applications(5), Receptor Mechanisms and Signaling(5), Sphingolipid Metabolism and Signaling(5), Neuroscience and Neuropharmacology Research(4)

Publications41 total

Accelerating Medicines Partnership® Parkinson's Disease Proteomics: A Comprehensive Resource for Advancing Parkinson's Disease Research
Movement Disorders·2026Open Access
Deep Learning Analysis on Images of iPSC-derived Motor Neurons Carrying fALS-genetics Reveals Disease-Relevant Phenotypes
2024· 10 citedOpen Access
In vitro assessment of the binding and functional responses of ozanimod and its plasma metabolites across human sphingosine 1-phosphate receptors
European Journal of Pharmacology·2022· 7 citedOpen Access
Preclinical target validation for non-addictive therapeutics development for pain
Expert Opinion on Therapeutic Targets·2022· 3 cited
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease
Science Translational Medicine·2022· 86 cited
Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5
Frontiers in Pharmacology·2022· 17 citedOpen Access
Imaging synaptic microstructure and synaptic loss <i>in vivo</i> in early Alzheimer’s Disease
2021· 2 citedOpen Access
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
Journal of Pharmacology and Experimental Therapeutics·2021· 8 citedOpen Access
Widespread cell stress and mitochondrial dysfunction in early Alzheimer’s Disease
2021· 7 citedOpen Access
Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
Drug Metabolism and Disposition·2021· 70 citedOpen Access
In Vitro Assessment of the Binding and Functional Reponses of Ozanimod and Its Circulating Metabolites Across Human Sphingosine 1-Phosphate Receptors (338)
Neurology·2020· 1 cited
Amyloid beta–positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity
Neurobiology of Aging·2018· 10 cited
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
Molecular Neurodegeneration·2017· 148 citedOpen Access
Discovery of MK-3168: A clinical PET tracer as a target engagement biomarker for FAAH
Abstracts of papers - American Chemical Society·2011
Ex Vivo Imaging of Pancreatic Beta Cells using a Radiolabeled GLP-1 Receptor Agonist
Molecular Imaging and Biology·2011· 44 cited
Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging.
PubMed·2011· 65 cited
Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions.
PubMed·2011· 108 cited
Chapter 8.1. Imaging as a CNS Biomarker
RSC drug discovery/RSC drug discovery series·2011· 1 cited
Biomarkers in Drug Development: A Handbook of Practice, Application, and Strategy. Edited by Michael R Bleavins, Claudio Carini, Mallé Jurima‐Romet and Ramin Rahbari.
ChemMedChem·2010
Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers
Clinical Pharmacology & Therapeutics·2010· 31 cited
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Frequent Co-authors

Lino Becerra(6), David Borsook(6), Waisi Eng(6), Koen Van Laere(6), Guy Bormans(6), Inge De Lepeleire(6), Julie V. Selkirk(5), Sandra Sanabria Bohórquez(5), Keith Gottesdiener(5), Sandra Sanabria(5), Yingzhuo Yan(4), Cyrille Sur(4), Eric D. Hostetler(4), Kerry Riffel(4), Jacquelynn J. Cook(4), H. Donald Burns(4), Terence G. Hamill(4), Nathan Ching(4), Jan de Hoon(4), Zhizhen Zeng(4)