Heather P. Harding

University of Cambridge — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

83h-index53.4kcitations174works1.72yr avg
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Research Topics

Endoplasmic Reticulum Stress and Disease(110), RNA regulation and disease(60), RNA Research and Splicing(28), Autophagy in Disease and Therapy(26), Pancreatic function and diabetes(19)

Publications172 total

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response
2025· 1 citedOpen Access
Metabolite import via SLC33A1 enables ATF6 activation by endoplasmic reticulum stress
2025· 1 citedOpen Access
Protocol for iterative enrichment of integrated sgRNAs via derivative CRISPR-Cas9 libraries from genomic DNA of sorted fixed cells
STAR Protocols·2024Open Access
Author response: A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
2024Open Access
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
eLife·2024Open Access
A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
2024Open Access
Author response: A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
2024Open Access
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
eLife·2024· 10 citedOpen Access
A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6⍺
2024Open Access
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response
Proceedings of the National Academy of Sciences·2024· 5 citedOpen Access
A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
2024Open Access
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells
The EMBO Journal·2023· 36 citedOpen Access
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response
2023Open Access
Infancy‐onset diabetes caused by de‐regulated <scp>AMPylation</scp> of the human endoplasmic reticulum chaperone <scp>BiP</scp>
EMBO Molecular Medicine·2023· 30 citedOpen Access
A homozygous p.(Arg371Ser) mutation in <i>FICD</i> de-regulates AMPylation of the human endoplasmic reticulum chaperone BiP causing infancy-onset diabetes and severe neurodevelopmental delay
2022Open Access
Higher-order phosphatase–substrate contacts terminate the integrated stress response
Nature Structural & Molecular Biology·2021· 33 citedOpen Access
Real-World, Patient-Reported and Clinic Data from Individuals with Type 1 Diabetes Using the MiniMed 670G Hybrid Closed-Loop System
Diabetes Technology & Therapeutics·2021· 18 cited
Higher order phosphatase-substrate contacts terminate the Integrated Stress Response
2021· 1 citedOpen Access
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
Cell Reports·2021· 37 citedOpen Access
Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Apollo (University of Cambridge)·2021Open Access
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Frequent Co-authors

David Ron(45), Yuhong Zhang(15), Isabel Novoa(8), Huiqing Zeng(7), Donalyn Scheuner(6), Randal J. Kaufman(6), Phoebe D. Lu(5), John C. Bell(4), Fumihiko Urano(4), Anne Bertolotti(4), Seiichi Oyadomari(4), Céline Jousse(4), Jaime D. Blais(4), Marcella A. Calfon(3), Chi Young Yun(3), Ira Tabas(3), Constantinos Koumenis(3), Nahum Sonenberg(3), Ronald C. Wek(2), Peter Chung(2)