Donalyn Scheuner

Indiana Biosciences Research Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index15.8kcitations59works4.72yr avg
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Research Topics

RNA regulation and disease(29), Endoplasmic Reticulum Stress and Disease(23), Pancreatic function and diabetes(15), Diabetes and associated disorders(8), RNA Research and Splicing(7)

Publications59 total

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
EBioMedicine·2025· 8 citedOpen Access
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
2024· 3 citedOpen Access
Pharmacological Inhibition of Tyrosine Protein-Kinase 2 Reduces Islet Inflammation and Delays Type 1 Diabetes Onset in Mice
SSRN Electronic Journal·2024· 3 citedOpen Access
25-OR: ADA Presidents' Select Abstract: Preclinical Evaluation of TYK2 Inhibitors in Type 1 Diabetes
Diabetes·2023· 1 cited
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype
Cell Metabolism·2021· 58 citedOpen Access
The Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress
Endocrinology·2021· 37 citedOpen Access
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
UNC Libraries·2020· 41 citedOpen Access
Adiponectin receptor fragmentation in mouse models of type 1 and type 2 diabetes
Archives of Autoimmune Diseases·2020· 3 citedOpen Access
Deoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype
SSRN Electronic Journal·2020· 2 citedOpen Access
Adiponectin Receptor Fragmentation in Mouse Models of Type 1 and Type 2 Diabetes
2019Open Access
PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity
eLife·2019· 95 citedOpen Access
Author response: PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity
2019· 1 citedOpen Access
Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in hIAPP transgenic mice
Diabetologia·2018· 9 citedOpen Access
A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
Pharmacology Research & Perspectives·2016· 22 citedOpen Access
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
PLoS Biology·2015· 198 citedOpen Access
Phosphorylation of eIF2α at Serine 51 Is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency
Molecular Biology of the Cell·2010· 112 citedOpen Access
Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity
Cell Host & Microbe·2010· 161 citedOpen Access
eIF2α Phosphorylation Tips the Balance to Apoptosis during Osmotic Stress
Journal of Biological Chemistry·2010· 99 citedOpen Access
Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2α Phosphorylation Pathway
Science Signaling·2009· 80 citedOpen Access
Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells
Cell Metabolism·2009· 361 citedOpen Access
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Frequent Co-authors

Randal J. Kaufman(37), David Ron(10), Heather P. Harding(9), Benbo Song(9), Antonis E. Koromilas(4), Carmella Evans‐Molina(4), Décio L. Eizirik(4), Yuhong Zhang(3), Maria Hatzoglou(3), Rupali Patel(3), Farooq Syed(3), Olivia Ballew(3), Chih‐Chun Lee(3), Jyoti Rana(3), Ângela Castela(3), Staci A. Weaver(3), Namratha Shivani Chalasani(3), Sofia Thomaidou(3), Stéphane Demine(3), Garrick Chang(3)