Pratiksha I. Thakore

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index9.7kcitations57works14.02yr avg
OpenAlex↗Google Scholar↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

CRISPR and Genetic Engineering(19), Immune Cell Function and Interaction(11), T-cell and B-cell Immunology(10), Single-cell and spatial transcriptomics(10), RNA Interference and Gene Delivery(8)

Publications57 total

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets
Cell Reports·2025· 2 citedOpen Access
Author Correction: Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Nature Biotechnology·2025Open Access
334 Computational mapping of CAR-T cell exhaustion through single-cell perturbation screens
Regular and Young Investigator Award Abstracts·2024Open Access
282 Improving solid tumor CAR-T therapies by modulating T cell transcriptional states using combinatorial <i>in vitro</i> CRISPR screening followed by <i>in vivo</i> validation
Regular and Young Investigator Award Abstracts·2024Open Access
Neuropeptide signalling orchestrates T cell differentiation
Nature·2024· 47 citedOpen Access
Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Nature Biotechnology·2024· 47 cited
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Nature Immunology·2024· 30 cited
Abstract 7042: Enhancing TCR T cell function in solid tumors through <i>in vivo</i> combinatorial screens and single-cell analysis
Cancer Research·2024
Abstract 7034: Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation
Cancer Research·2024
Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq
2023· 22 citedOpen Access
Author Correction: Massively parallel phenotyping of coding variants in cancer with Perturb-seq
Nature Biotechnology·2022· 1 citedOpen Access
Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing
Nature Biotechnology·2022· 49 citedOpen Access
CRISPR screens reveal neuropeptide signaling orchestrates T helper cell differentiation
2022Open Access
Single cell RNA-seq by mostly-natural sequencing by synthesis
2022· 1 citedOpen Access
The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states
2022· 12 citedOpen Access
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
Immunity·2022· 162 citedOpen Access
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
Cell·2021· 233 citedOpen Access
Cycling cancer persister cells arise from lineages with distinct programs
Nature·2021· 476 citedOpen Access
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
Cell·2021· 463 citedOpen Access
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
Nature Biotechnology·2021· 518 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

Aviv Regev(22), Charles A. Gersbach(17), Orit Rozenblatt–Rosen(16), Alexandra Schnell(10), Vijay K. Kuchroo(10), David G. Ousterout(8), Shomyseh Sanjabi(8), Timothy E. Reddy(7), Ami M. Kabadi(7), Elena Christian(7), Chao Wang(5), Gregory E. Crawford(4), Farshid Guilak(4), Christopher E. Nelson(4), Yaara Oren(4), Michael S. Cuoco(4), Heidie Frisco Cabanos(4), Aaron N. Hata(4), Joan S. Brugge(4), Sarah Zaghouani(4)